Intensive protein synthesis in neurons and phosphorylation of beta-amyloid precursor protein and tau-protein are triggering factors of neuronal amyloidosis and Alzheimer's disease
1. Russian Gerontological Research Clinical Center, Russian Ministry of Health Care; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences 2. Insitute of Protein Research, Russian Academy of Sciences 3. Institute of Biophysics Cell, Russian Academy of Sciences 4. Institute of Neurology, Psychiatry and Addiction Medical Sciences of Ukraine 5. MDSICI M.F. Vladimirsky 6. Russian Gerontological Research Clinical Center, Russian Ministry of Health Care 7. Insitute of Protein Research, Russian Academy of Sciences; State Research Center for Applied Microbiology & Biotechnology
Recently the studies of Alzheimer’s disease have become particularly actual and have attracted scientists from all over the world to this problem as a result of dissemination of this dangerous disorder. The reason for such pathogenesis is not known, but the final image, for the first time obtained on microscopic brain sections from patients with this disease more than a hundred years ago, is well known to clinicists. This is the deposition of Ab amyloid in the brain tissue of senile plaques and fibrils. Many authors suppose that the deposition of beta-amyloid provokes secondary neuronal changes which are the reason of neuron death. Other authors associate the death of neurons with hyperphosphorylation of tau-proteins which form neurofibrillar coils inside nerve cells and lead to their death. For creation of methods of preclinical diagnostics and effective treatment of Alzheimer’s disease novel knowledge is required on the nature of triggering factors of sporadic isoforms of Alzheimer’s disease, on cause-effect relationships of phosphorylation of amyloid precursor protein with formation of pathogenic beta-amyloids, on the relationship with these factors of hyperphosphorylation of tau-protein and neuron death. In this review we analyze the papers describing the increasing of intensity of biosynthesis in neurons in normal conditions and under the stress, the possibility of development of energetic unbalanced neurons and activation of their protective systems. Phosphorylation and hyperphosphorylation of tau-proteins is also tightly connected with protective mechanisms of cells and with processes of evacuation of phosphates, adenosine mono-phosphates and pyrophosphates from the region of protein synthesis. Upon long and high intensity of protein synthesis the protective mechanisms are overloaded and the complementarity of metabolitic processes is disturbed. This results in dysfunction of neurons, transport collapse, and neuron death.
Maltsev A.V., Dovidchenko N.V., Uteshev V.K., Sokolik V.V., Shtang O.M., Yakushin M.A., Sokolova N.M., Surin A.K., Galzitskaya O.V. (2013) Intensive protein synthesis in neurons and phosphorylation of beta-amyloid precursor protein and tau-protein are triggering factors of neuronal amyloidosis and Alzheimer's disease. Biomeditsinskaya Khimiya, 59(2), 144-170.
Maltsev A.V. et al. Intensive protein synthesis in neurons and phosphorylation of beta-amyloid precursor protein and tau-protein are triggering factors of neuronal amyloidosis and Alzheimer's disease // Biomeditsinskaya Khimiya. - 2013. - V. 59. -N 2. - P. 144-170.
Maltsev A.V. et al., "Intensive protein synthesis in neurons and phosphorylation of beta-amyloid precursor protein and tau-protein are triggering factors of neuronal amyloidosis and Alzheimer's disease." Biomeditsinskaya Khimiya 59.2 (2013): 144-170.
Maltsev, A. V., Dovidchenko, N. V., Uteshev, V. K., Sokolik, V. V., Shtang, O. M., Yakushin, M. A., Sokolova, N. M., Surin, A. K., Galzitskaya, O. V. (2013). Intensive protein synthesis in neurons and phosphorylation of beta-amyloid precursor protein and tau-protein are triggering factors of neuronal amyloidosis and Alzheimer's disease. Biomeditsinskaya Khimiya, 59(2), 144-170.
Sallaw A., Mintzez J., Weiner M., Cummings J. (2008) J. Alzheimer’s Dementia, 4, 65-79. Scholar google search
Maltsev A.V., Galzitskaya O.V. (2010) Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases, Biomeditsinskaya Khimiya vol: 56(6), 624-638 CrossRef Scholar google search
Low L.F., Anstey K.J. (2009) J. Alzheimer’s Dementia, 5, 43-49. Scholar google search
Meek P.D., McKeithan K., Schumock G.T. (1998) Pharmacotherapy, 18(2 Pt 2), 68-73. Scholar google search
Li W.Z., Li W.P., Huang D.K., Kan H.W., Wang X., Wu W.Y., Yin Y.Y., Yao Y.Y. (2012) Behav. Brain. Res., 227(1), 142-149. CrossRef Scholar google search
Rogaev E.I. (1999) Bolezn Alzheimera i starenie: ot nejrobiologii k terapii. M. NZPZ RAMS, c. 83-86. Scholar google search
Johnson G.V., Bailey C.D. (2002) J. Alzheimers Dis., 4, 375-398. Scholar google search
Ksiezak-Reding H., Tracz E., Yang L.S., Dickson D.W., Simon M., Wall J.S. (1996) Am. J. Pathol., 149(2), 639-651. Scholar google search
Mori H., Hosoda K., Matsubara E., Shoji M., Maruyama S., Hirai S. (1995) Neurosci. Lett., 186(2-3), 181-183. CrossRef Scholar google search
Iqbal K., Alonso-Adel C., Chen S., Chohan M.O., El-Akkad E., Gong C.X., Khatoon S., Li B., Liu F., Rahman A., Tanimukai H., Grundke-Iqbal I. (2005) Biochim. Biophys. Acta, 1739(2-3), 198-210. CrossRef Scholar google search
Raevskij K.S. (1988) Vozbuzhdajushhie aminokisloty kak translittery Itogi nauki i tehniki VINITI. Ser. “Fiziologija cheloveka i zhivotnyh”. M., t. 36. Scholar google search
Behtereva N.P. (1988) Zdorovyj i bol'noj mozg cheloveka, L., Izd-vo “Nauka”, pp 262 Scholar google search
Iwata A., Chen X.H., McIntosh T.K., Browne K.D., Smith D.H. (2002) J. Neuropathol Exp Neurol., 61, 1056-1068. Scholar google search
Iwata A., Chen X.H., McIntosh T.K., Browne K.D., Thal D.R., Glas A., Schneider W., Schober R. (1997) Acta Neuropathol., 94, 255-265. CrossRef Scholar google search
Stone J.R., Okonkwo D.O., Singleton R.H., Mutlu L.K., Helm G.A., Povlishock J.T. (2002) J. Neurotrauma, 19, 601-614. CrossRef Scholar google search
Wallace W., Ahlers S.T., Gotlib J., Bragin V., Sugar J., Gluck R., Shea P.A., Davis K.L., Haroutunian V. (1993) Proc. Natl. Acad. Sci. USA., 90, 8712-8716. CrossRef Scholar google search
Narayan P., Meehan S., Carver J.A., Wilson M.R., Dobson C.M., Klenerman D. (2012) Biochemistry, 51(46), 9270-9276. CrossRef Scholar google search
Ghiso J., Shayo M., Calero M., Ng D., Tomidokoro Y., Gandy S., Rostagno A., Frangione B. (2004) J. Biol. Chem., 279(44), 45897-45908. CrossRef Scholar google search
Choi B.H., Kim R.C., Vaughan P.J., Lau A., van Nostrand W.E., Cotman C.W., Cunningham D.D. (1995) Neurobiol Aging, 16, 557-562. CrossRef Scholar google search
Furukawa K., Sopher B.L., Rydel R.E., Begley J.G., Pham D.G., Martin G.M., Fox M., Mattson M.P. (1996) J. Neurochem., 67, 1882-1896. CrossRef Scholar google search
de Strooper B., Annaert W. (2000) J. Cell Sci., 113, 1857-1870. Scholar google search
Wasco W., Bupp K., Magendantz M., Gusella J.F., Tanzi R.E., Solomon F. (1992) Proc. Natl. Acad.Sci. USA, 89, 10758-10762. CrossRef Scholar google search
Wasco W., Gurubhagavatula S., Paradis M.D., Romano D.M., Sisodia S.S., Hyman B.T., Neve R.L., Tanzi R.E. (1993) Nat.Genet., 5, 95-100. CrossRef Scholar google search
Kang J., Lemaire H.G., Unterbeck A. (1987) Nature, 325, 733-736. Scholar google search
Molinari M., Eriksson K.K., Ca-lanca V., Galli C., Cresswell P., Michalak M., Helenius A. (2004) Mol. Cell, 13(1), 125-135. Scholar google search
Prillet C., Bauer T., Mitteregger G., Krebs B., Kretzschmar H.A., Herms J. (2006) J. Neurosci., 26(27), 7212-7221. Scholar google search
Turner P.R., O’Connor K., Tate W.C. (2003) Prog. Neurobiol., 70(1), 1-32. Scholar google search
Alonso A.S., Li V., Grundke-Iqbal I., Iqbal K. (2006) Proc. Natl. Acad. Sci. USA, 103(23), 8864-8869.
. Scholar google search
von Bergen M., Friedhoff P., Bienart J., Heberle J., Mandelkow E.-M., Mandelkow E. (2000) Proc. Natl. Acad. Sci. USA, 97(10), 5129-5134. CrossRef Scholar google search
Brandt R., Leger J., Lee G. (1995) J. Cell. Biol., 131, 1327-1340. Scholar google search
Chen J., Kanai Y., Cowan N., Hirokawa N. (1992) Nature, 360, 674-677. Scholar google search
Johnson G.V., Jenkins S.M. (1999) J. Alzheimers Dis., 1, 307-328. Scholar google search
Cripps D., Thomas S.N., Jeng Y., Yang F., Davies P., Yang A.J. (2006) J. Biol. Chem., 281(16), 10825-10838. CrossRef Scholar google search
Kuhla B., Haase C., Flach K. (2007) J. Biol. Chem., 282(10), 6984-6991. Scholar google search
Biernat J., Gustke N., Drewes G., Mandelkow E.M., Mandelkow E. (1993) Neuron, 11, 153-163. Scholar google search
Probst A., Gotz J., Wiederhold K.H., Tolnay M., Mistl C., Jaton A.L., Hong M., Ishihara T., Lee V.M., Trojanowski J.Q., Jakes R., Crowther R.A., Spillantini M.G., Burki K., Goedert M. (2000) Acta Neuropathol., 99, 469-481. Scholar google search
Dawson H.N., Ferreira A., Eyster M.V., Ghoshal N., Binder L.I., Vitek M.P. (2001) J. Cell Sci., 114, 1179-1187. Scholar google search
Rizzu P., Van Swieten JC., Joosse M., Hasegawa M., Stevens M., Tibben A., Niermeijer M.F., Hillebrand M., Ravid R., Oostra B.A., Goedert M., van Duijn C.M., Heutink P. (1999) Am. J. Hum. Genet., 64, 414-421. CrossRef Scholar google search
Baker M., Litvan I., Houlden H., Adamson J., Dickson D., Perez-Tur J., Hardy J., Lynch T., Bigio E., Hutton M. (1999) Hum. Mol. Genet., 8, 711-715. CrossRef Scholar google search
Hong M., Zhukaeva V., Vogelsberg-Ragagila V., Wszolek Z., Reed L., Miller B.I., Geschwind D.H., Bird T.D., McKeel D., Goate A., Morris J.C., Wilhelmsen K.C., Schellenberg G.D., Trojanowski J.Q., Lee V.M. (1998) Science, 282, 1914-1917. CrossRef Scholar google search
Ryoo S.R., Jeong H.K., Radnaabazar C., Yoo J.J., Cho H.J., Lee H.W., Kim I.S., Cheon Y.H., Ahn Y.S., Chung S.H., Song W.J. (2007) J. Biol. Chem., 282(48), 34850-34857. CrossRef Scholar google search
Grundke-Iqbal I., Iqbal K., Tung Y.C., Quinlan M., Wisniewski H.M., Binder L.I. (1986) Proc. Natl. Acad. Sci. USA, 83, 4913-4917. CrossRef Scholar google search
Spires T.L., Orne J.D., SantaCruz K., Pitstick R., Carlson G.A., Ashe K.H., Hyman B.T. (2006) Am. J. Pathol., 168, 1598-1607. CrossRef Scholar google search
Buee L., Bussiere T., Buee-Scherrer V., Delacourte A., Hof P.R. (2000) Brain Res. Rev., 33, 95-130. CrossRef Scholar google search
Goedert M., Spillantini M.G., Jakes R., Rutherford D., Crowther R.A. (1989) Neuron, 3, 519-526. CrossRef Scholar google search
Kopke E., Tung Y.C., Shaikh S., Alonso A.C., Iqbal K., Grundke-Iqbal I. (1993) J. Biol. Chem., 268, 24374-24384. Scholar google search
Delacourte A., David J.P., Sergeant N., Buee L., Wattez A., Vermersch P., Ghozali F., Fallet-Bianco C., Pasquier F., Lebert F., Petit H., Di Menza C. (1999) Neurology, 52, 1158-1165. CrossRef Scholar google search
Sjoberg M.K., Shestakova E., Mansuroglu Z., Maccioni R.B., Bonnefoy E. (2006) J. Cell Sci., 119, 2025-2034. CrossRef Scholar google search
Korenberg J.R., Chen X.N., Schipper R., Sun Z., Gonsky R., Gerwehr S., Carpenter N., Daumer C., Dignan P., Disteche C. (1994) Proc. Natl. Acad. Sci. USA, 91, 4997-5001. CrossRef Scholar google search
Goedert M., Satumtira S., Jakes R., Smith M.J., Kamibayashi C., White C.L. 3rd, Sontag E. (2000) J. Neurochem., 75, 2155-2162. CrossRef Scholar google search
Walter J., Capell A., Hung A.Y., Langen H., Schnoelzer M., Thinakaran G., Sisodia S.S., Selkoe D.J., Haass C. (1997) J. Biol. Chem. 272, 1896-1903. CrossRef Scholar google search
Wallace W., Ahlers S.T., Gotlib J., Bragin V., Sugar J., Gluck R., Shea P.A., Davis K.L, Haroutunian V. (1993) Proc. Natl. Acad. Sci. USA. 90, 8712-8716. CrossRef Scholar google search
Spittaels K., van den Haute C., van Dorpe J., Geerts H., Mercken M., Bruynseels K., Lasrado R., Vandezande K., Laenen I., Boon T., Van Lint J., Vandenheede J., Moechars D., Loos R., Van Leuven F. (2000) J. Biol. Chem., 275, 41340-41349. CrossRef Scholar google search
Abraha A., Ghoshal N., Gamblin T.C., Cryns V., Berry R.W., Kuret J., Binder L.I. (2000) J. Cell Sci., 113, 3737-3745. Scholar google search
Filosto M., Scarpelli M., Cotelli M.S., Vielmi V., Todeschini A., Gregorelli V., Tonin P., Tomelleri G., Padovani A. (2011) J. Neurol., 258(10), 1763-1774. CrossRef Scholar google search
Facecchia K., Fochesato L.A., Ray S.D., Stohs S.J., Pandey S. (2011) J. Toxicol., 2011, 683-728. CrossRef Scholar google search
UVERSKII V.N., GALZITSKAIA O.V., WINTER S., KITTLER L., LÖBER G. (1999) Cell and Tissue Biology, 41, 540-549. Scholar google search
Masliah E., Sisk A., Mallory M., Mucke L., Schenk D., Games D. (1996) J. Neurosci., 16 (18), 5795-811. Scholar google search
Niedowicz D.M., Beckett T.L., Matveev S., Weidner A.M., Baig I., Kryscio R.J., Mendiondo M.S., LeVine H. 3rd, Keller J.N., Murphy M.P. (2012) Ann. Neurol., 72(4), 564-570. CrossRef Scholar google search
Hampel H., Wilcock G., Andrieu S., Aisen P., Blennow K., Broich K., Carrillo M., Fox N.C., Frisoni G.B., Isaac M., Lovestone S., Nordberg A., Prvulovic D., Sampaio C., Scheltens P., Weiner M., Winblad B., Coley N., Vellas B. (2011) Progress in Neurobiology, 95, 579-593. CrossRef Scholar google search
