Conotoxins: from the biodiversity of gastropods to new drugs

   
Fedosov A.E.1 , Moshkovskii S.A.2 , Kuznetsova K.G.3, Olivera B.M.4

1. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences; Department of Biology, University of Utah
2. Institute of Biomedical Chemistry, Russian Academy of Medical Science
3. Institute of Biomedical Chemistry, Russian Academy of Medical Science; Biological Faculty, Lomonosov Moscow State University
4. Department of Biology, University of Utah
Section: Review
DOI: 10.18097/pbmc20135903267      UDK: 577.1; 574.5; 615.3      PubMed Id: 23987066
Year: 2013  Volume: 59  Issue: 3  Pages: 267-294
A review describes general trends in research of conotoxins that are peptide toxins isolated from sea gastropods of the Conus genus, since the toxins were discovered in 1970 . There are disclosed a conotoxin classification, their structure diversity and different ways of action to their molecular targets, mainly, ion channels. In the applied aspect of conotoxin research, drug discovery and development is discussed, the drugs being based on conotoxin structure. A first exemplary drug is a ziconotide, which is an analgesic of new generation.
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Fedosov A.E., Moshkovskii S.A., Kuznetsova K.G., Olivera B.M. (2013) Biomeditsinskaya khimiya, 59(3), 267-294.
This paper is also available as the English translation:10.1134/S1990750812020059
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