1. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences; Department of Biology, University of Utah 2. Institute of Biomedical Chemistry, Russian Academy of Medical Science 3. Institute of Biomedical Chemistry, Russian Academy of Medical Science; Biological Faculty, Lomonosov Moscow State University 4. Department of Biology, University of Utah
A review describes general trends in research of conotoxins that are peptide toxins isolated from sea gastropods of the Conus genus, since the toxins were discovered in 1970 . There are disclosed a conotoxin classification, their structure diversity and different ways of action to their molecular targets, mainly, ion channels. In the applied aspect of conotoxin research, drug discovery and development is discussed, the drugs being based on conotoxin structure. A first exemplary drug is a ziconotide, which is an analgesic of new generation.
Download PDF:
Keywords: conotoxin, conopeptide, gastropod, ion channel, drug
Citation:
Fedosov A.E., Moshkovskii S.A., Kuznetsova K.G., Olivera B.M. (2013) Conotoxins: from the biodiversity of gastropods to new drugs. Biomeditsinskaya Khimiya, 59(3), 267-294.
Fedosov A.E. et al. Conotoxins: from the biodiversity of gastropods to new drugs // Biomeditsinskaya Khimiya. - 2013. - V. 59. -N 3. - P. 267-294.
Fedosov A.E. et al., "Conotoxins: from the biodiversity of gastropods to new drugs." Biomeditsinskaya Khimiya 59.3 (2013): 267-294.
Fedosov, A. E., Moshkovskii, S. A., Kuznetsova, K. G., Olivera, B. M. (2013). Conotoxins: from the biodiversity of gastropods to new drugs. Biomeditsinskaya Khimiya, 59(3), 267-294.
Kohn A.J. (1963) In: Venomous and poisonous animals and noxious plants of the Pacific area (Keegan H.L., ed.), Pergamon Press, NY., pp. 83-96. Scholar google search
Loughnan M., Bond T., Atkins A., Cuevas J., Adams D.J, Broxton N.M., Livett B.G., Down J.G., Jones A., Alewood P.F. (1998) J. Biol. Chem., 273, 15667-15674. Scholar google search
Cruz L.J., Gray W.R., Olivera B.M., Zeikus R.D., Kerr L., Yoshikami D., Moczydlowski E. (1985) J. Biol. Chem., 260, 9280-9288. Scholar google search
Cruz L.J., Kupryszewski G., LeCheminant G.W., Gray W.R., Olivera B.M., Rivier J. (1989) Biochemistry, 28, 3437-3442. CrossRef Scholar google search
Becker S., Prusak-Sochaczewski E., Zamponi G., Beck-Sickinger A.G., Gordon R.D., French R.J. (1992) Biochemistry, 31, 8229-8238. CrossRef Scholar google search
Shon K.J., Olivera B.M., Watkins M., Jacobsen R.B., Gray W.R., Floresca C.Z., Cruz L.J., Hillyard D.R., Brink A., Terlau H., Yoshikami D. (1998) J. Neurosci., 18, 4473-4481. Scholar google search
Nielsen K.J., Watson M., Adams D.J., Hammarstroem A.K., Gage P.W., Hill J.M., Craik D.J., Thomas L., Adams D., Alewood P.F., Lewis R.J. (2002) J. Biol. Chem., 277, 27247-27255. CrossRef Scholar google search
Zhang M.M., Green B.R., Catlin P., Fiedler B., Azam L., Chadwick A., Terlau H., McArthur J.R., French R.J., Gulyas J., Rivier J.E., Smith B.J., Norton R.S., Olivera B.M., Yoshikami D., Bulaj G. (2007) J. Biol. Chem., 282, 30699-30706. CrossRef Scholar google search
Zhang M.M., Fiedler B., Green B.R., Catlin P., Watkins M., Garrett J.E., Smith B.J., Yoshikami D.B., Olivera M., Bulaj G. (2006) Biochemistry, 45, 3723-3732. CrossRef Scholar google search
Terlau H., Stocker M., Shon K.J., McIntosh J.M., Olivera B.M. (1996) J. Neurophysiol., 76, 1423-1429. Scholar google search
Bulaj G., Zhang M.M., Green B.R., Fiedler B., Layer R.T., Wei S., Nielsen J.S., Low S.J., Klein B.D., Wagstaff J.D., Chicoine L., Harty T.P., Terlau H., Yoshikami D., Olivera B.M. (2006) Biochemistry, 45, 7404-7414. CrossRef Scholar google search
Daly N.L., Ekberg J.A., Thomas L.D., Adams J., Lewis R.J., Craik D.J. (2004) J. Biol. Chem., 279, 25774-25782. CrossRef Scholar google search
Ekberg J., Jayamanne A., Vaughan C.W., Aslan S., Thomas L., Mould J., Drinkwater R., Baker M.D., Abrahamsen B., Wood J.N., Adams D.J., Christie M.J., Lewis R.J. (2006) PNAS, 103, 17030-17035. CrossRef Scholar google search
McIntosh J.M., Hasson A., Spira M.E., Gray W.R., Li W., Marsh M., Hillyard D.R., Olivera B.M. (1995) J. Biol. Chem., 270, 16796-16802. CrossRef Scholar google search
Safo P., Rosenbaum T., Shcherbatko A., Choi D.Y., Han E., Toledo-Aral J.J., Olivera B.M., Brehm P., Mandel G. (2000) J. Neuroscience, ???, 76-80. Scholar google search
Zorn S., Leipold E., Hansel A., Bulaj G., Olivera B.M., Terlau H., Heinemann S.H. (2006) FEBS Lett., 580, 1360-1364. CrossRef Scholar google search
Fainzilber M., Lodder J.C., van der Schors R.C., Li K.W., Yu Z., Burlingame A.L., Geraerts W.P., Kits K.S. (1996) Biochemistry, 35, 8748-8752. CrossRef Scholar google search
Barbier J., Lamthanh H., Le Gall F., Favreau P., Benoit E., Chen H., Gilles N., Ilan N., Heinemann S.H., Gordon D., Menez A., Molgo J. (2004) J. Biol. Chem., 279, 4680-4685. CrossRef Scholar google search
Terlau H., Shon K.J., Grilley M., Stocker M., Stuehmer W., Olivera B.M. (1996) Nature, 381, 148-151. CrossRef Scholar google search
Ferber M., Sporning A., Jeserich G., DeLaCruz R., Watkins M., Olivera B.M., Terlau H. (2003) J. Biol. Chem., 278, 2177-2183. CrossRef Scholar google search
Jimenez E.C., Shetty R.P., Lirazan M., Rivier M., Walker C., Abogadie F.C., Yoshikami D., Cruz L.J., Olivera B.M. (2003) J. Neurochem., 85, 610-621. CrossRef Scholar google search
Baumann A., Grupe A., Ackermann A., Pongs O. (1988) EMBO J., 7, 2457-2463. Scholar google search
Zhang S.J., Yang X.M., Liu G.S., Cohen M.V., Pemberton K., Downey J.M. (2003) J. Cardiovasc. Pharmacol., 42, 764-771. CrossRef Scholar google search
Lubbers N.L., Campbell T.J., Polakowski J.S., Bulaj G., Layer R.T., Moore J., Gross G.J., Cox B.F. (2005) J. Cardiovasc. Pharmacol., 46, 141-146. CrossRef Scholar google search
Jacobsen R.B., Koch E.D., Lange-Malecki B., Stocker M., Verhey J., van Wagoner R.M., Vyazovkina A., Olivera B.M., Terlau H. (2000) J. Biol. Chem., 275, 24639-24644. CrossRef Scholar google search
Dauplais M., Lecoq A., Song J., Cotton J., Jamin N., Gilquin B., Roumestand C., Vita C., de Medeiros C.L., Rowan E.G., Harvey A.L., Menez A. (1997) J. Biol. Chem., 272, 4302-4309. CrossRef Scholar google search
Savarin P., Guenneugues M., Gilquin B., Lamthanh H., Gasparini S., Zinn-Justin S., Menez A. (1998) Biochemistry, 37, 5407-5416. CrossRef Scholar google search
Le Gall F., Favreau P., Benoit E., Mattei C., Bouet F., Menou J.L., Menez A. Letourneux Y., Molgo J. (1999) Eur. J. Neurosci., 11, 3134-3142. CrossRef Scholar google search
Al-Sabi A., Lennartz D., Ferber M., Gulyas J., Rivier J.F., Olivera B.M., Carlomagno T., Terlau H. (2004) Biochemistry, 43, 8625-8635. CrossRef Scholar google search
Kauferstein S., Huys I., Lamthanh H., Stoecklin R., Sotto F., Menez A., Tytgat J., Mebs D. (2003) Toxicon, 42, 43-52. CrossRef Scholar google search
Sudarslal S., Majumdar S., Ramasamy P., Dhawan R., Pal P.P., Ramaswami M., Lala A.K., Sikdar S.K., Sarma S.P., Krishnan K.S., Balaram P. (2003) FEBS Lett., 553, 209-212. CrossRef Scholar google search
Catterall W.A., Striessnig J., Snutch T.P., Perez-Reyes E. (2003) Pharmacol. Rev., 55, 579-581. CrossRef Scholar google search
Ertel E.A., Campbell K.P., Harpold M.M., Hofmann F., Mori Y., Perez-Reyes E., Schwartz A., Snutch T.P., Tanabe T., Birnbaumer L., Tsien R.W., Catterall W.A. (2000) Neuron, 25, 533-535. CrossRef Scholar google search
Lew M.J., Flinn J.P., Pallaghy P.K., Murphy R., Whorlow S.L., Wright C.E., Norton R.S., Angus J.A. (1997) J. Biol. Chem., 272, 12014-12023. CrossRef Scholar google search
Nielsen K.J., Adams D.A., Alewood P.F., Lewis R.J., Thomas L., Schroeder T., Craik D.J. (1999) Biochemistry, 38, 6741-6751. CrossRef Scholar google search
Nadasdi L., Yamashiro D., Chung D., Tarczy-Hornoch K., Adriaenssens P., Ramachandran J. (1995) Biochemistry, 34, 8076-8081. CrossRef Scholar google search
Kobayashi T., Kobayashi M., Gryczynski Z., Lakowicz J.R., Collins J.H. (2000) Biochemistry, 39, 86-91. CrossRef Scholar google search
Hansson K., Ma X., Eliasson L., Czerwiec E., Furie B., Furie B.C., Rorsman P., Stenflo J. (2004) J. Biol. Chem., 279, 32453-32463. CrossRef Scholar google search
Gotti C., Clementi F., Fornari A., Gaimarri A., Guiducci S., Manfredi I., Moretti M., Pedrazzi P., Pucci L., Zoli M. (2009) Biochem. Pharmacol., 78, 703-711. CrossRef Scholar google search
van Wagoner R.M., Jacobsen R.B., Olivera B.M., Ireland C.M. (2003) Biochemistry, 42, 6353-6362. CrossRef Scholar google search
England L.J., Imperial J., Jacobsen R., Craig A.G., Gulyas J., Akhtar M., Rivier J., Julius D., Olivera B.M. (1998) Science, 281, 575-578. CrossRef Scholar google search
Nagasawa M., Sakimura K., Mori K.J., Bedell M.A., Copeland N.G., Jenkins N.A., Mishina M. (1996) Brain Res., 36, 1-11. CrossRef Scholar google search
Czerwiec E., Begley G.S., Bronstein M., Stenflo J., Taylor K., Furie B.C., Furie B. (2002) Eur. J. Biochem., 269, 6162-6172. CrossRef Scholar google search
Williams A.J., Ling G., McCabe R.T., Tortella F.C. (2002) Neuroreport, 13, 821-824. Scholar google search
Sharpe I.A., Thomas L., Loughnan M., Motin L., Palant E., Croker D.E., Alewood D., Chen S., Graham R.M., Alewood P.F., Adams D.J., Lewis R.J. (2003) J. Biol. Chem., 278, 34451-34457. Scholar google search
Bryan-Lluka L.J., Boenisch H., Lewis R.J. (2003) J. Biol. Chem., 278, 40324-40329. Scholar google search
Lean M.E.J., Mann J.I., Hoek J.A., Elliot R.M., Schofield G. (2008) Brit. Med. J., 337, a863. Scholar google search
