Prooxidant and antioxidant activity of blood plasma and histology of internal organs of rats after intravenous administration of magnetite nanoparticles

   
Milto I.V.1 , Klimenteva T.K.2, Suhodolo I.V.2, Krivova N.A.3

1. Siberian State Medical University; National Research Tomsk Polytechnic University
2. Siberian State Medical University
3. Scientific Research Institute of Biology and Biophysics
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20135903330      PubMed Id: 23987070
Year: 2013  Volume: 59  Issue: 3  Pages: 330-338
The effect of a single and multiple intravenous injections of a nanosized magnetite suspension on total prooxidant and antioxidant activity of blood plasma has been investigated by the method of luminol-dependent chemoluminescence. Magnetite nanoparticles possess dose-dependent prooxidant properties due to their iron atoms and at the same time their trigger compensatory activation of antioxidant systems in the rat blood plasma. After a single intravenous administration of magnetite the studied parameters of blood plasma returned to the normal level by the end of the experiment as due to removal of nanoparticles from the body. In the case of multiple administration of the magnetite suspension dose-dependent changes in the pro- and antioxidant plasma activity persist during the whole experiment. Accumulation of magnetite particles in the cells of the mononuclear phagocytic system in the rats’ liver, lungs and kidneys is associated with hemodynamic damages, local dystrophic and necrotic changes of parenchyma in these organs. After a single intravenous injection magnetite nanoparticles are identified in the rat organs for 40 days, but their number decreases by the end of the experiment.
Download PDF:
Keywords: nanomagnetite, blood plasma, prooxidant and antioxidant activity
Citation:

Milto, I. V., Klimenteva, T. K., Suhodolo, I. V., Krivova, N. A. (2013). Prooxidant and antioxidant activity of blood plasma and histology of internal organs of rats after intravenous administration of magnetite nanoparticles. Biomeditsinskaya khimiya, 59(3), 330-338.
This paper is also available as the English translation: 10.1134/S1990750812030110
References  
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)