Photo-activity of actinomycins

   
Vekshin N.L.1

1. Institute of Cell Biophysics
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20135903349      PubMed Id: 23987072
Year: 2013  Volume: 59  Issue: 3  Pages: 349-357
Using actinomycins as an example, the possibility of increasing the anti-tumor activity of heterocyclic antibiotics due to photo-activation, has been studied. In model experiments with solutions of actinomycins, it was showed that actinomycins have a significant photochemical activity (of its own), changing by the binding to DNA in solution or in tumor cells. Photo-destruction of HeLa cells and the release of the antibiotic were observed.
Download PDF:
Keywords: anti-cancer antibiotics, actinomycin, 7-amino-actinomycin D, fluorescence, HeLa cells, photo-destruction, caffeine
Citation:

Vekshin, N. L. (2013). Photo-activity of actinomycins. Biomeditsinskaya khimiya, 59(3), 349-357.
References  
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)