Study of surface-active properties antivirials compound 1-boraadamantane for model monomoleculars phosphlipids layers

   
Kontarov N.A.1 , Pogarskaya I.V.1, Balaev N.V.1, Yuminova N.V.1

1. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20135905519      PubMed Id: 24479341
Year: 2013  Volume: 59  Issue: 5  Pages: 519-522
The surface-active properties of 1-boraadamantane have been studied using model phospholipid monolayers. Results suggest that the increase in 1-boraadamantane concentrations from 10-7 to 10-6 M is accompanied by the increase of the area per phospholipid molecule. This decreases to frequency of lateral diffusion of phospholipids molecules, the potential difference and the angle of the phospholipid monolayer arrangement. These phenomena may lead to impossibility of interaction between the virus and cell membranes.
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Keywords: 1-boraadamantane, influenza virus, phospholipid monolayers, compression isotermes
Citation:

Kontarov, N. A., Pogarskaya, I. V., Balaev, N. V., Yuminova, N. V. (2013). Study of surface-active properties antivirials compound 1-boraadamantane for model monomoleculars phosphlipids layers. Biomeditsinskaya khimiya, 59(5), 519-522.
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