1. ANO “Institute of Biomedical Problems” 2. ANO “Institute of Biomedical Problems”; Lomonosov Moscow State University 3. Central Clinic Hospital of Civil Aviation 4. Russian Children’s Clinical Hospital 5. ANO “Institute of Biomedical Problems”; Research Institute of Human Morphology of the Russian Academy of Medical Sciences
Proinsulin content was measured in the serum of 82 children (aged from 3 to 14 years) with type 1 diabetes mellitus of various duration. Three groups of patients characterized by low (54%), normal (42%) and high (4%) levels of this prohormone were recognized. No dependence the proinsulin level on the disease term was found. The serum proinsulin level may be used as a parameter specifying the pathogenesis of type 1 diabetes mellitus.
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Keywords: diabetes mellitus type 1, proinsulin
Citation:
Lotosh N.Y., Selishcheva A.A., Nadorov S.A., Badyshtov B.A., Volkov I.E., Saveljev S.V. (2013) The proinsulin level in the blood of children with type 1 diabetes mellitus of various duration. Biomeditsinskaya Khimiya, 59(5), 563-569.
Lotosh N.Y. et al. The proinsulin level in the blood of children with type 1 diabetes mellitus of various duration // Biomeditsinskaya Khimiya. - 2013. - V. 59. -N 5. - P. 563-569.
Lotosh N.Y. et al., "The proinsulin level in the blood of children with type 1 diabetes mellitus of various duration." Biomeditsinskaya Khimiya 59.5 (2013): 563-569.
Lotosh, N. Y., Selishcheva, A. A., Nadorov, S. A., Badyshtov, B. A., Volkov, I. E., Saveljev, S. V. (2013). The proinsulin level in the blood of children with type 1 diabetes mellitus of various duration. Biomeditsinskaya Khimiya, 59(5), 563-569.
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