Drug delivery system on the base of phospholipid nanoparticles for rifampicin

Sanzhakov M.A.1, Prozorovskyi V.N.1, Ipatova O.M.1, Tikhonova E.G.1, Medvedeva N.V.1, Torkhovskaya T.I.1

1. Institute of Biomedical Chemistry RAMS
Section: Short Communication
DOI: 10.18097/PBMC20135905585      PubMed Id: 24479349
Year: 2013  Volume: 59  Issue: 5  Pages: 585-590
Low bioavailability of rifampicin, one of the main antituberculous drug, stimulates searches of its new optimized formulations. The present study has showen possibility of rifampicin embedding into nanoparticles from plant phosphatidylcholine (diameter of 20-30 nm). Addition of sodium oleate to the phospholipid system caused a 2-fold increase of the percent of rifampicin incorporation. After oral administration to rats, the maximal drug observed in plasma one hour after was 0.5 and 4.2 mkg/ml for free rifampicin for rifampicin in phospholipids-oleate nanoparticles, respectively. These levels were maintained for more than two hours of the experiment. High rifampicin bioavailability in the oleate containing phospholipid nanosystem suggests prospectivity of its pharmaceutical elaboration.
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Keywords: tuberculosis treatment, rifampicin, nanoparticles, phospholipids, oleate, bioavailability

Sanzhakov, M. A., Prozorovskyi, V. N., Ipatova, O. M., Tikhonova, E. G., Medvedeva, N. V., Torkhovskaya, T. I. (2013). Drug delivery system on the base of phospholipid nanoparticles for rifampicin. Biomeditsinskaya Khimiya, 59(5), 585-590.
This paper is also available as the English translation: 10.1134/S1990750814020127
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