Drug delivery system on the base of phospholipid nanoparticles for rifampicin

   
Sanzhakov M.A.1, Prozorovskyi V.N.1, Ipatova O.M.1, Tikhonova E.G.1, Medvedeva N.V.1, Torkhovskaya T.I.1

1. Institute of Biomedical Chemistry RAMS
Section: Short Communication
DOI: 10.18097/pbmc20135905585      UDK: 615.032      PubMed Id: 24479349
Year: 2013  Volume: 59  Issue: 5  Pages: 585-590
Low bioavailability of rifampicin, one of the main antituberculous drug, stimulates searches of its new optimized formulations. The present study has showen possibility of rifampicin embedding into nanoparticles from plant phosphatidylcholine (diameter of 20-30 nm). Addition of sodium oleate to the phospholipid system caused a 2-fold increase of the percent of rifampicin incorporation. After oral administration to rats, the maximal drug observed in plasma one hour after was 0.5 and 4.2 mkg/ml for free rifampicin for rifampicin in phospholipids-oleate nanoparticles, respectively. These levels were maintained for more than two hours of the experiment. High rifampicin bioavailability in the oleate containing phospholipid nanosystem suggests prospectivity of its pharmaceutical elaboration.
Download PDF:
Reference:

Sanzhakov M.A., Prozorovskyi V.N., Ipatova O.M., Tikhonova E.G., Medvedeva N.V., Torkhovskaya T.I. (2013) Biomeditsinskaya khimiya, 59(5), 585-590.
This paper is also available as the English translation:10.1134/S1990750814020127
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)
        

© Institute of Biomedical Chemistry, Moscow, Russia