Hypoxic preconditioning modifies the activity of prond antioxidant systems in rat hippocampus

   
Kislin M.S.1, Stroev S.A.2, Gluschenko T.S.1, Tulkova E.I.1 , Pelto-Huikko M.3, Samoilov M.O.1

1. Pavlov Institute of Physiology RAS
2. Pavlov Institute of Physiology RAS; Tampere Unviersity
3. Tampere Unviersity
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20135906673      UDK: 577.352      PubMed Id: 24511679
Year: 2013  Volume: 59  Issue: 6  Pages: 673-681
The effects of repetitive mild hypobaric hypoxic preconditioning upon pro- and antioxidant systems in rat hippocampus were studied. It was found that three-trial preconditioning by mild hypobaric hypoxia (360 mm Hg, 2 h) induced moderate oxidative stress immediately after the last preconditioning trial. In addition, it down-regualted the levels of peptide antioxidants (Trx-1, Trx-2, Cu,Zn-SOD) and several lipid peroxidation products 24 h later.
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Kislin M.S., Stroev S.A., Gluschenko T.S., Tulkova E.I., Pelto-Huikko M., Samoilov M.O. (2013) Biomeditsinskaya khimiya, 59(6), 673-681.
This paper is also available as the English translation:10.1134/S1990750812040051
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