Critical conditions as a logical and appropriate chain of iron methabolism disorders (the summary of experimental studies)

   
Orlov Y.P.1 , Lukach V.N.1, Dolgih V.T.1, Soboleva E.L.2, Ivanov A.V.1, Ivanova A.M.1, Boltruchenko A.S.1, Boronenko V.V.1, Kozhevnikova E.F.1, Pozharov S.V.1

1. Omsk State Medical Academy
2. Irkutsk regional of "Badge of Honor" order clinical hospital
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20135906700      PubMed Id: 24511682
Year: 2013  Volume: 59  Issue: 6  Pages: 700-709
It is revealed that in all models of critical conditions will activate the free-radical oxidation, decreasing the total antioxidant activity, the concentration of transferrin decreases in the serum of the blood, increase of the concentration of ferritin, the rheological properties of the blood are violated and the signs of endothelial dysfunction are identified. Pre-entered deferoxamine in the dose of 80 mg/kg reduced the intensity of free-radical oxidation processes, restoring the antioxidant potential, concentration of the transferrin, and a lower level of ferritin, contributed to the normalization of blood rheological properties and a reduction of the extent endothelium destruction as a result of the reduction Fe2+ concentration in blood serum.
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Keywords: transferrin, ferritin, microcirculation, von Willebrand factor, deferoxamine
Citation:

Orlov, Y. P., Lukach, V. N., Dolgih, V. T., Soboleva, E. L., Ivanov, A. V., Ivanova, A. M., Boltruchenko, A. S., Boronenko, V. V., Kozhevnikova, E. F., Pozharov, S. V. (2013). Critical conditions as a logical and appropriate chain of iron methabolism disorders (the summary of experimental studies). Biomeditsinskaya khimiya, 59(6), 700-709.
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