1. Far East Federal University 2. Far East Federal University; Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science (FEB RAS) 3. Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science (FEB RAS) 4. Medical Association, FEB RAS 5. Far East Federal University; Medical Association, FEB RAS; ul. Kirova, 95, Vladivostok, Russia 6. Pacific Research Fisheconomic center
The effects of the small doses of the preparation Gistochrome, containing natural polyhydroxynaphtoquinoine echinochrom A from flat sea urchin Scaphechinus mirabilis , on blood biochemical parameters have been studied in patients with cardiovascular diseases. Gistochrome administration influenced the LPO-antioxidant protection system, indicating reinforcement of antioxidant protection mechanisms. Gistochrome modulated the immune status and the plasma cytokine profile. Thus, Gistochrome may be recommended as means of additional therapy for patients with cardiovascular diseases for correcting the metabolic, immunological and redox impairments.
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Keywords: echinochrome A, 1,4-naphtoquinone, pharmacological activity, mechanism of action, cardiovascular diseases
Citation:
Tsybulsky A.V., Popov A.M., Artyukov A.A., Krivoshapko O.N., Kozlovskaya E.P., Bogdanovich L.N., Krijanovsky S.P., Blinov Yu.G. (2014) The effects of preparation “histochrom” in biochemical parameters of blood for patients with cardiopathologies. Biomeditsinskaya Khimiya, 60(1), 115-124.
Tsybulsky A.V. et al. The effects of preparation “histochrom” in biochemical parameters of blood for patients with cardiopathologies // Biomeditsinskaya Khimiya. - 2014. - V. 60. -N 1. - P. 115-124.
Tsybulsky A.V. et al., "The effects of preparation “histochrom” in biochemical parameters of blood for patients with cardiopathologies." Biomeditsinskaya Khimiya 60.1 (2014): 115-124.
Tsybulsky, A. V., Popov, A. M., Artyukov, A. A., Krivoshapko, O. N., Kozlovskaya, E. P., Bogdanovich, L. N., Krijanovsky, S. P., Blinov, Yu. G. (2014). The effects of preparation “histochrom” in biochemical parameters of blood for patients with cardiopathologies. Biomeditsinskaya Khimiya, 60(1), 115-124.
