Mass spectrometry of blood low-molecular fraction as a method for unification of therapeutic drug monitoring

Lokhov P.G.1 , Maslov D.L.1, Trifonova O.P.1, Balashova E.E.1, Archakov A.I.1

1. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20146002201      UDK: 543.51.061:543.54.45:543.8      PubMed Id: 24837310
Year: 2014  Volume: 60  Issue: 2  Pages: 201-216
The article describes a new therapeutic drug monitoring (TDM) method based on direct infusion of low-molecular fraction of blood into electrospray ionization source of mass spectrometer. This technique allows performing TDM of almost all drugs used in clinic. In article, the universality and high-throughput of the method, that significantly simplifies its wide application, have been shown. Moreover, the possibility of method application in most cases of drug therapy has been argued as a tool of control of drug doses, rationality of drug therapy, and the quality of the drugs themselves. In conclusion, the prospects for application of the method as primary means of improving the quality and personalization of drug therapy have been discussed.
Download PDF:

Lokhov P.G., Maslov D.L., Trifonova O.P., Balashova E.E., Archakov A.I. (2014) Biomeditsinskaya khimiya, 60(2), 201-216.
This paper is also available as the English translation:10.1134/S1990750814010119
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)