Mass spectrometry of blood low-molecular fraction as a method for unification of therapeutic drug monitoring

   
Lokhov P.G.1 , Maslov D.L.1, Trifonova O.P.1, Balashova E.E.1, Archakov A.I.1

1. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20146002201      UDK: 543.51.061:543.54.45:543.8      PubMed Id: 24837310
Year: 2014  Volume: 60  Issue: 2  Pages: 201-216
The article describes a new therapeutic drug monitoring (TDM) method based on direct infusion of low-molecular fraction of blood into electrospray ionization source of mass spectrometer. This technique allows performing TDM of almost all drugs used in clinic. In article, the universality and high-throughput of the method, that significantly simplifies its wide application, have been shown. Moreover, the possibility of method application in most cases of drug therapy has been argued as a tool of control of drug doses, rationality of drug therapy, and the quality of the drugs themselves. In conclusion, the prospects for application of the method as primary means of improving the quality and personalization of drug therapy have been discussed.
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Lokhov P.G., Maslov D.L., Trifonova O.P., Balashova E.E., Archakov A.I. (2014) Biomeditsinskaya khimiya, 60(2), 201-216.
This paper is also available as the English translation:10.1134/S1990750814010119
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