1. Saint-Petersburg State University, Institute of toxicology, Federal Medico-Biological Agency 2. Saint-Petersburg State University 3. Institute of toxicology, Federal Medico-Biological Agency
Methods of whole blood trace element determination by Graphite furnace atomic absorption spectrometry (in the variant of Zeeman’s modulation polarization spectrometry) have been proposed. They do not require preliminary sample digestion. Furnace programs, modifiers and blood dilution factors were optimized. Seronorm™ human whole blood reference materials were used for validation. Dynamic ranges (for undiluted blood samples) were: Al 8 ¸ 210 мg/L; Be 0.3 ¸ 50 мg/L; Cd 0.2 ¸ 75 мg/L; Сo 5 ¸ 350 мg/L; Cr 10 ¸ 100 мg/L; Mn 6 ¸ 250 мg/L; Ni 10 ¸ 350 мg/L; Pb 3 ¸ 240 мg/L; Se 10 ¸ 500 мg/L; Tl 2 ¸ 600 мg/L. Precision (RSD) for the middle of dynamic range ranged from 5% for Mn to 11 for Se.
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Keywords: atomic absorption spectrometry, blood, trace element assessment, analysis of complicated matrices without preliminary sample digestion
Citation:
Ivanenko N.B., Ivanenko A.A., Solovyev N.D., Navolotskii D.V., Pavlova O.V., Ganeev A.A. (2014) Determination of Al, Be, Cd, Co, Cr, Mn, Ni, Pb, Se and Tl in whole blood by atomic absorption spectrometry without preliminary sample digestion. Biomeditsinskaya Khimiya, 60(3), 378-388.
Ivanenko N.B. et al. Determination of Al, Be, Cd, Co, Cr, Mn, Ni, Pb, Se and Tl in whole blood by atomic absorption spectrometry without preliminary sample digestion // Biomeditsinskaya Khimiya. - 2014. - V. 60. -N 3. - P. 378-388.
Ivanenko N.B. et al., "Determination of Al, Be, Cd, Co, Cr, Mn, Ni, Pb, Se and Tl in whole blood by atomic absorption spectrometry without preliminary sample digestion." Biomeditsinskaya Khimiya 60.3 (2014): 378-388.
Ivanenko, N. B., Ivanenko, A. A., Solovyev, N. D., Navolotskii, D. V., Pavlova, O. V., Ganeev, A. A. (2014). Determination of Al, Be, Cd, Co, Cr, Mn, Ni, Pb, Se and Tl in whole blood by atomic absorption spectrometry without preliminary sample digestion. Biomeditsinskaya Khimiya, 60(3), 378-388.
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