Defensins – natural peptide antibiotics of higher eucariotes

Grishin D.V.; Sokolov N.N.

doi:10.18097/PBMC20146004438

Defensins – natural peptide antibiotics of higher eucariotes

Grishin D.V.¹, Sokolov N.N.¹

1. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Medical Sciences

Section: Review

DOI: 10.18097/PBMC20146004438 PubMed Id: 25249527

Year: 2014 Volume: 60 Issue: 4 Pages: 438-447

The goal of this review is to characterize defensins representing an evolutionary the most ancient family of antimicrobial peptides. It gives general information on functional and structural features of defensins as the main components of the first-line defense of higher eukaryote organisms against infectious agents. The review considers not only current situation in the defensin research but also perspectives of creation of recombinant antimicrobial peptides of biomedical application.

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Keywords: antimicrobial peptides, defensins, mechanism of bactericidal action of defensins, recombinant antimicrobial peptides

Citation:

Grishin, D. V., Sokolov, N. N. (2014). Defensins – natural peptide antibiotics of higher eucariotes. Biomeditsinskaya Khimiya, 60(4), 438-447.

This paper is also available as the English translation: 10.1134/S1990750814010077

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