Defensins – natural peptide antibiotics of higher eucariotes

   
Grishin D.V.1 , Sokolov N.N.1

1. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Medical Sciences
Section: Review
DOI: 10.18097/pbmc20146004438      UDK: 571.27, 577.181.7      PubMed Id: 25249527
Year: 2014  Volume: 60  Issue: 4  Pages: 438-447
The goal of this review is to characterize defensins representing an evolutionary the most ancient family of antimicrobial peptides. It gives general information on functional and structural features of defensins as the main components of the first-line defense of higher eukaryote organisms against infectious agents. The review considers not only current situation in the defensin research but also perspectives of creation of recombinant antimicrobial peptides of biomedical application.
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Grishin D.V., Sokolov N.N. (2014) Biomeditsinskaya khimiya, 60(4), 438-447.
This paper is also available as the English translation:10.1134/S1990750814010077
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