Protective properties of recombinant igA1 protease from meningococcus

Kotel’nikova O.V.1 , Alliluev A.P.2, Drozhzhina E.Yu.1, Koroleva I.S.3, Sitnikova E.A.1, Zinchenko A.A.1, Gordeeva E.A.1, Melikhova T.D.1, Nokel E.A.1, Zhigis L.S.1, Zueva V.S.1, Razgulyaeva O.A.1, Serova O.V.1, Yagudaeva E.Yu.1, Rumsh L.D.1

1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
2. Medical Faculty, Russian University of Peoples’ Friendship
3. Municipal infectious deceases hospital №2, Moscow, Russia
Section: Clinical Study
DOI: 10.18097/PBMC20146004479      PubMed Id: 25249532
Year: 2014  Volume: 60  Issue: 4  Pages: 479-486
The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form showed that active form of IgA1 protease exhibited species – and type-specificity for mouse and human immunoglobulins. Mutant form, which did not exhibit enzymatic activity, had protective properties against meningococcal infection, induced by meningococcus serogroup A, B and C protecting the mice from lethal infection by living virulent culture of heterologous serogroups of meningococcus. Obtained results make it possible to consider IgA1 protease as a perspective preparation at the stages of development of polyvalent vaccine for protection the people from meningococcal infection of various etiology
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Keywords: IgA1 protease, meningococcal vaccine, enzymatic activity, immunogenicity, protective properties

Kotel’nikova, O. V., Alliluev, A. P., Drozhzhina, E. Yu., Koroleva, I. S., Sitnikova, E. A., Zinchenko, A. A., Gordeeva, E. A., Melikhova, T. D., Nokel, E. A., Zhigis, L. S., Zueva, V. S., Razgulyaeva, O. A., Serova, O. V., Yagudaeva, E. Yu., Rumsh, L. D. (2014). Protective properties of recombinant igA1 protease from meningococcus. Biomeditsinskaya Khimiya, 60(4), 479-486.
This paper is also available as the English translation: 10.1134/S1990750813040033
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