Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of drosophila melanogaster

   
Latypova E.M.1, Timoshenko S.I.1, Kislik G.A.1, Vitek M.P.2, Schwarzman A.L.3, Sarantseva S.V.1

1. Petersburg Institute of Nuclear Physics
2. Division of Neurology, Duke University Medical Center
3. Petersburg Institute of Nuclear Physics; Institute for Experimental Medicine, Russian Academy of Medical Sciences
Section: Clinical Study
DOI: 10.18097/pbmc20146004515      UDK: 577.112.6      PubMed Id: 25249536
Year: 2014  Volume: 60  Issue: 4  Pages: 515-521
The neuroprotective activity of apolipoprotein E (apoE) peptide mimetic Cog1410, containing amino acid sequence of the receptor-binding domain apoE, has been investigated in transgenic lines of Drosophila melanogaster expressing human APP and beta-secretase. Expression of two transgenes caused neuropathological processes attributed to Alzheimer's disease: neurodegeneration, cognitive abnormality and amyloid deposits formation in brain. It was shown that Cog 1410 reduces neurodegeneration in brain of transgenic flies and improves cognitive functions (odor recognition). These data suggest that Cog1410 is a potential neuroprotector that can be used in AD treatment.
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Latypova E.M., Timoshenko S.I., Kislik G.A., Vitek M.P., Schwarzman A.L., Sarantseva S.V. (2014) Biomeditsinskaya khimiya, 60(4), 515-521.
This paper is also available as the English translation:10.1134/S1990750814010107
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