The influence of a single injection of haloperidol on basic carboxypeptidases (biologically active peptide processing enzymes) activity in rat tissues was studied. Acute exposure to haloperidol increased the activity of carboxypeptidases H (CP H) in hypothalamic-pituitary-adrenal system and cerebellum and reduced such activity in testes. Multidirectional changes of PMSF-inhibited carboxypeptidases activity (PMSF-CP) were observed after a single haloperidol injection in all studied tissues except testes. It is suggested that changes of CP H and PMSF-CP activity might affect levels of regulatory peptides in the brain and blood and thus may be involved in general and side effects of haloperidol on the organism.
Pravosudova N.A., Bykova I.O. (2014) Comparison of basic carboxypeptidases activity in male rats tissues at a single injection of haloperidol. Biomeditsinskaya Khimiya, 60(5), 548-552.
Pravosudova N.A. et al. Comparison of basic carboxypeptidases activity in male rats tissues at a single injection of haloperidol // Biomeditsinskaya Khimiya. - 2014. - V. 60. -N 5. - P. 548-552.
Pravosudova N.A. et al., "Comparison of basic carboxypeptidases activity in male rats tissues at a single injection of haloperidol." Biomeditsinskaya Khimiya 60.5 (2014): 548-552.
Pravosudova, N. A., Bykova, I. O. (2014). Comparison of basic carboxypeptidases activity in male rats tissues at a single injection of haloperidol. Biomeditsinskaya Khimiya, 60(5), 548-552.
