Comparison of basic carboxypeptidases activity in male rats tissues at a single injection of haloperidol

   
Pravosudova N.A.1 , Bykova I.O.1

1. Penza State University
Section: Experimental Study
DOI: 10.18097/pbmc20146005548      UDK: 577.152.342      PubMed Id: 25386883
Year: 2014  Volume: 60  Issue: 5  Pages: 548-552
The influence of a single injection of haloperidol on basic carboxypeptidases (biologically active peptide processing enzymes) activity in rat tissues was studied. Acute exposure to haloperidol increased the activity of carboxypeptidases H (CP H) in hypothalamic-pituitary-adrenal system and cerebellum and reduced such activity in testes. Multidirectional changes of PMSF-inhibited carboxypeptidases activity (PMSF-CP) were observed after a single haloperidol injection in all studied tissues except testes. It is suggested that changes of CP H and PMSF-CP activity might affect levels of regulatory peptides in the brain and blood and thus may be involved in general and side effects of haloperidol on the organism.
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Pravosudova N.A., Bykova I.O. (2014) Biomeditsinskaya khimiya, 60(5), 548-552.
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