Effect of 17b-estradiol on bioenergetic processes in the heart mitochondria of ovariectomized rats with insulin resistance

   
Gorbenko N.I.1 , Borikov A.Y.1, Ivanova O.V.1, Taran E.V.1, Zvyagina T.S.1

1. Institute of Endocrine Pathology Problems
Section: Experimental Study
DOI: 10.18097/pbmc20146005576      PubMed Id: 25386887
Year: 2014  Volume: 60  Issue: 5  Pages: 576-580
Тhe bioenergetic processes in the heart mitochondria of Wistar rats with fructose-induced insulin resistance was investigated in female animals with different estrogen status. Respiration studies on isolated heart mitochondria by the polarographic method revealed that estrogen deficiency reduced complex IV activity, while its combination with high-fructose diet induced additional disturbances in the coupling of respiration and oxidative phosphorylation at the level of complex I of the electron transport chain. Exogenous 17b-estradiol inhibited the development of mitochondrial dysfunction in cardiomyocytes of ovariectomized rats with insulin resistance.
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Keywords: estrogen deficiency, 17b-estradiol, insulin resistance, mitochondrial dysfunction, cardiomyocytes
Citation:

Gorbenko, N. I., Borikov, A. Y., Ivanova, O. V., Taran, E. V., Zvyagina, T. S. (2014). Effect of 17b-estradiol on bioenergetic processes in the heart mitochondria of ovariectomized rats with insulin resistance. Biomeditsinskaya khimiya, 60(5), 576-580.
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