Imbalance of system of glutamin – glutamic acid in the placenta and amniotic fluid at placental insufficiency

Pogorelova T.N.1 , Gunko V.O.1, Linde V.A.1

1. Rostov Scientific-Research Institute of Obstetrics and Pediatrics
Section: Clinical Study
DOI: 10.18097/pbmc20146005596      UDK: 577.112.3+677.15+618.46+612.649+618.396+618.3-06+618.396      PubMed Id: 25386890
Year: 2014  Volume: 60  Issue: 5  Pages: 596-601
Metabolism of glutamine and glutamic acid has been investigated in the placenta and amniotic fluid under conditions of placental insufficiency. The development of placental insufficiency is characterized by the increased content of glutamic acid and a decrease of glutamine in both placenta and amniotic fluid. These changes changes were accompanied by changes in the activity of enzymes involved in the metabolism of these amino acids. There was a decrease in glutamate dehydrogenase activity and an increase in glutaminase activity with the simultaneous decrease of glutamine synthetase activity. The compensatory decrease in the activity of glutamine keto acid aminotransferase did not prevent a decrease in the glutamine level. The impairments in the system glutamic acid-glutamine were more pronounced during the development of premature labor.
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Pogorelova T.N., Gunko V.O., Linde V.A. (2014) Biomeditsinskaya khimiya, 60(5), 596-601.
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