Extracting and study of biochemical properties of thiamine pyrophosphokinase from non-malignant and tumor tissue of myometrium

   
Orishaka O.V.1 , Vovchuk I.L.1, Petrov S.A.1

1. Mechnikov Odessa National University
Section: Clinical Study
DOI: 10.18097/pbmc20146005602      PubMed Id: 25386891
Year: 2014  Volume: 60  Issue: 5  Pages: 602-607
The method of extraction and purification of thiamine pyrophosphokinase from non-malignant and tumor tissue of myometrium has been elaborated. Kinetic characteristics of T-kinase from non-malignant and tumor tissue of women myometrium have been studied. It has been shown, that malignization of myometrium is accompanied by a decrease in affinity of thiamine pyrophosphokinase from tumor to thiamine and by an increase in sensitivity of the enzyme from tumor to thiochrome.
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Keywords: thiamine pyrophosphokinase, thiamine, thiochrome, inhibition, myometrium
Citation:

Orishaka, O. V., Vovchuk, I. L., Petrov, S. A. (2014). Extracting and study of biochemical properties of thiamine pyrophosphokinase from non-malignant and tumor tissue of myometrium. Biomeditsinskaya khimiya, 60(5), 602-607.
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