In-vitro degradation of the chitosan membranes under various syntheses conditions

Kalinkevich O.V.1, Pogorielov M.V.2 , Babich I.M.2, Deyneka V.N.2, Kalinkevich A.N.1, Danilchenko S.N.1, Tkach G.F.2

1. Institute of Applied Physics of National Academy of Sciences of Ukraine, Sumy, Ukraine
2. Sumy State University, Medical Institute
Section: Experimental Study
DOI: 10.18097/PBMC20146006636      PubMed Id: 25552502
Year: 2014  Volume: 60  Issue: 6  Pages: 636-642
The hydrolytic degradation of polymer films, which were obtained by application of 2% and 3% chitosan solutions in 1% acetic acid on a base sheet has been investigated. As the solvent was removed, these firms were either treated with 0.5% NaOH for 3 min or with phosphate buffer (рН 8) for 10 min. The degrees of degradation for the obtained samples were studied during 1-96 h in solutions with pH values of 5.0, 7.0 and 8.5. The results revealed resistance of the films within the first 6 h, followed by their subsequent degradation. The rate of degradation depended on pH of the solution, chitosan percentage and the treatment methods of films. The materials with the initial chitosan content of 3% were more resistant to the hydrolytic degradation, but the decreasing in pH accelerated the weight loss of the film. However, if the membranes were treated with phosphate buffer, the rate and degree of sample degradation were slowed down. Thus, the results are considered as a basis for the further development of biomaterials to treat the skin surface damages.
Download PDF:  
Keywords: chitosan, biocompositions, hydrolytic degradation

Kalinkevich, O. V., Pogorielov, M. V., Babich, I. M., Deyneka, V. N., Kalinkevich, A. N., Danilchenko, S. N., Tkach, G. F. (2014). In-vitro degradation of the chitosan membranes under various syntheses conditions. Biomeditsinskaya Khimiya, 60(6), 636-642.
 2024 (vol 70)
 2023 (vol 69)
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)