Production of nitric oxide metabolites during transplanted tumors growth with different metastatic potential

Deryagina V.P.1 , Ryzhova N.I.1, Krivosheeva L.V.1, Golubeva I.S.2

1. Institute of Carcinogenesis, Blokhin Russian Cancer Research Center
2. Institute of Experimental Diagnostics and Therapy of Cancer, Blokhin Russian Cancer Research Center, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20146006661      PubMed Id: 25552506
Year: 2014  Volume: 60  Issue: 6  Pages: 661-667
The endogenous formation of metabolites of NO – nitrite (NI), nitrates (NA) and volatile nitrosamines in the body, tumor tissue and by abdominal cavity by macrophages for dynamics was investigated in mice F1(C57BlxCBA), Balb/c and BDF with subcutaneous transplanted tumors (Erlich carcinoma – EC and metastatic Lewis lung carcinoma – LLC). It was shown that growth of EC was accompanied by a statistically significant increase in the concentrations of NI and NA in tumor tissue to (7.3±4.67)´10-6 – (7.8±2.57)´10-5 (mol/kg) for the first three weeks and a sharp increase in urinary excretion of NI and NA. The maximum total concentration of NI and NA – (3.,6±0.46)´10-5 in tissue LLC was registered during the early stage of the tumor growth (7 days); it later declined, negatively correlating with the mass of the tumor. NI secretion by abdominal cavity macrophages demonstrated statistically significantly decrease at the stage of intensive growth LLC (14, 21 days). The tissue of EC contained varied concentration of cancerogenic N-nitrosodimethylamine and N-nitrosodiethylamine at all investigated time points. Thus, the ability of different gistogenesis tumor tissue to synthesize metabolites NO depended on time parameters and was more pronounced for EC, than LLC.
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Keywords: biosynthesis of nitrites, nitrates, N-nitrosamines, tumoral tissue, macrophages, Ehrlich carcinoma, Lewis lung carcinoma

Deryagina, V. P., Ryzhova, N. I., Krivosheeva, L. V., Golubeva, I. S. (2014). Production of nitric oxide metabolites during transplanted tumors growth with different metastatic potential. Biomeditsinskaya Khimiya, 60(6), 661-667.
This paper is also available as the English translation: 10.1134/S1990750815020055
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