NMR study of human biological fluids for detection of pathologies

Beskaravainy P.M.1 , Molchanov M.V.1, Suslikov A.V.2, Paskevich S.I.1, Kutyshenko V.P.1, Vorob’ev S.I.3

1. Institute of Theoretical and Experimental Biophysics RAS, Pushchino, Russia
2. Federal Hospital Pushchino Research Center RAS, Moscow region, Pushchino, Russia
3. Sechenov First Moscow State Medical University, Moscow, Russia
Section: Clinical Study
DOI: 10.18097/PBMC20156101141      PubMed Id: 25762608
Year: 2015  Volume: 61  Issue: 1  Pages: 141-149
The paper deals with the NMR spectra obtained using preparations of five different human biological body fluids. Characteristic metabolite signals of blood, urine, tears, saliva, and sweat spectra have been determined and classified. The biological body fluid samples were used for search and identification of biomarkers of cardiovascular disease. Absolute functional biomarkers for diseases such as coronary heart disease (CHD) have not been recognized even in the case acute myocardial infarction. A hypothesis explaining reasons of lack of such markers has been formulated. The results of comparative analysis of blood and urine samples from humans and some laboratory animals are given. Identify and analyze signals of metabolites of pathogenic microflora and their dynamics in the urine from patients with urogenital diseases have been determined and analyzed and characteristic biomarkers have been recognized.
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Keywords: biological fluids, NMR, biomarkers

Beskaravainy, P. M., Molchanov, M. V., Suslikov, A. V., Paskevich, S. I., Kutyshenko, V. P., Vorob’ev, S. I. (2015). NMR study of human biological fluids for detection of pathologies. Biomeditsinskaya Khimiya, 61(1), 141-149.
This paper is also available as the English translation: 10.1134/S1990750814020024
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