Development of noninvasive bladder cancer diagnosis on basis of telomerase and it’s subunits hTERT and hTR detection

   
Glukhov A.I.1 , Grigorieva Y.E.2, Gordeev S.A.2, Vinarov A.Z.2, Potoldykova N.V.2

1. Sechenov First Moscow State Medical University, Moscow, Russia; Kurchatov NBIC Centre, NRC “Kurchatov Institute”, Moscow, Russia
2. Sechenov First Moscow State Medical University, Moscow, Russia
Section: Clinical Study
DOI: 10.18097/PBMC20156101150      PubMed Id: 25762609
Year: 2015  Volume: 61  Issue: 1  Pages: 150-160
Telomerase activity (TA) and expression of genes coding it’s subunits (hTERT and hTR) have been examined in tumor tissue and urine sediment samples taken from patients with bladder cancer (BC) using the modified TRAP assay (in the case of telomerase detection) and RT-PCR (in the case of hTERT and hTR expression). Results obtained in this study demonstrate possibility of noninvasive diagnosis of BC with sensitivity of 96% and specificity of 100% in the case of telomerase detection and with sensitivity of 80% and specificity of 100% in the case of hTERT detection in urine sediment samples.
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Keywords: bladder cancer (BC), telomerase, catalytic subunit of telomerase (hTERT), RNA-subunit of telomerase (hTR), diagnosis, noninvasive diagnosis
Citation:

Glukhov, A. I., Grigorieva, Y. E., Gordeev, S. A., Vinarov, A. Z., Potoldykova, N. V. (2015). Development of noninvasive bladder cancer diagnosis on basis of telomerase and it’s subunits hTERT and hTR detection. Biomeditsinskaya Khimiya, 61(1), 150-160.
This paper is also available as the English translation: 10.1134/S1990750814010053
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