Role of angiostatins in diabetic complications

Tykhomyrov A.A.; Shram S.I.; Grinenko T.V.

doi:10.18097/PBMC20156101041

Role of angiostatins in diabetic complications

Tykhomyrov A.A.¹, Shram S.I.², Grinenko T.V.¹

1. Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kiev, Ukraine
2. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

Section: Review

DOI: 10.18097/PBMC20156101041 PubMed Id: 25762598

Year: 2015 Volume: 61 Issue: 1 Pages: 41-56

Angiogenesis is a process through which new blood vessels form from pre-existing vessels. Angiogenesis is regulated by a number of factors of peptide nature. Disbalance of angiogenic system appears to be the major causative factor contributing vascular abnormalities in diabetes mellitus, resulting in various complications. Angiostatins, which are kringle-containing fragments of plasminogen/plasmin, are known to be powerful physiological inhibitors of neovascularization. In the present review, current literature data on peculiarities of production of angiostatins and their functioning at diabetes mellitus are summarized and analyzed for the first time. Also, role of angiostatins in the pathogenesis of typical diabetic complications, including retinopathies, nephropathies and cardiovascular diseases, is discussed. Data presented in this review may be useful for elaboration of novel effective approaches for diagnostics and therapy of vascular abnormalities in diabetes mellitus.

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Keywords: angiostatins, kringle domains, plasminogen, diabetes mellitus, vascular abnormalities

Citation:

Tykhomyrov, A. A., Shram, S. I., Grinenko, T. V. (2015). Role of angiostatins in diabetic complications. Biomeditsinskaya Khimiya, 61(1), 41-56.

This paper is also available as the English translation: 10.1134/S1990750814020140

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