In this review we discuss the molecular mechanisms of insulin resistance concomitant with metabolic inflammation. We also analyze the world results of experimental and clinical studies which aimed at identifying the molecular targets for the development of new prevention and treatment of insulin resistance.
Download PDF:
Keywords: obesity, type 2 diabetes, metabolic syndrome, insulin resistance
Litvinova L.S. et al. Insulin resistance pathogenesis in metabolic obesity // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 1. - P. 70-82.
Litvinova L.S. et al., "Insulin resistance pathogenesis in metabolic obesity." Biomeditsinskaya Khimiya 61.1 (2015): 70-82.
Litvinova, L. S., Kirienkova, E. V., Mazunin, I. O., Vasilenko, M. A., Fattakhov, N. S. (2015). Insulin resistance pathogenesis in metabolic obesity. Biomeditsinskaya Khimiya, 61(1), 70-82.
Skolnik E.Y., Batzer A., Li N., Lee C.H., Lowenstein E., Mohammadi M., Margolis B., Schlessinger J. (1993) Science, 260(5116), 1953–1955. CrossRef Scholar google search
Gureasko J., Galush W.J., Boykevisch S., Sondermann H., Bar-Sagi D., Groves J.T., Kuriyan J. (2008) Nat. Struct. Mol. Biol., 15, 452–461. CrossRef Scholar google search
Combettes-Souverain M., Issad T. (1998) Diabetes Metab., 24, 477–489. Scholar google search
Somwar R., Kim D.Y., Sweeney G., Huang C., Niu W., Lador C., Ramlal T., Klip A. (2001) Biochem. J., 359, 639–649. CrossRef Scholar google search
Newsholme P., Haber E.P., Hirabara S.M.,Rebelato E.L., Procopio J., Morgan D.,Oliveira-Emilio H.C., Carpinelli A.R., Curi R. (2007)J. Physiol., 583, 9–24. CrossRef Scholar google search
Brehm A., Krssak M., Schmid A.I., Nowotny P., Waldhäusl W., Roden M. (2006) Diabetes, 55, 136–140. CrossRef Scholar google search
Lenoir O., Flosseau K., Ma F.X., Blondeau B., Mai A., Bassel-Duby R., Ravassard P., Olson E.N., Haumaitre C., Scharfmann R. (2011) Diabetes, 60, 2861–2871. CrossRef Scholar google search
Rajendran R., Garva R., Krstic-Demonacos M., Demonacos C. (2011) J. Biomed. Biotechnol., 2011, ID 368276. Scholar google search
Turu M.M., Slevin M., Matou S., West D., Rodríguez C., Luque A., Grau-Olivares M., Badimon L., Martinez-Gonzalez J., Krupinski J. (2008) BMC Cell. Biol., 9, 47. CrossRef Scholar google search
Kim H.S., Han M.S., Chung K.W., Kim S., Kim E., Kim M.J., Jang E., Lee H.A., Youn J., Akira S., Lee M.S. (2007) Immunity, 27(2), 321–333. CrossRef Scholar google search
Kopp A., Buechler C., Bala M., Neumeier M., Schölmerich J., Schäffler A. (2010) Endocrinology, 151, 1097–1108. CrossRef Scholar google search
Haversen L., Danielsson K.N., Fogelstrand L., Wiklund O. (2009) Atherosclerosis, 202, 382–393. CrossRef Scholar google search
Wen H., Gris D., Lei Y., Jha S., Zhang L., Huang M.T., Brickey W.J. Ting J.P. (2011) Nat. Immunol., 12, 408–415. CrossRef Scholar google search
Rydén M., Dicker A., Van Harmelen V., Hauner H., Brunnberg M., Perbeck L., Lonnqvist F., Arner P. (2002) J. Biol. Chem., 277, 1085-1091. CrossRef Scholar google search
Davis H.M., Carpenter D.C., Stahl J.M., Zhang W., Hynicka W.P., Griswold D.E. (2000) J. Immunol. Methods, 240, 125–132. CrossRef Scholar google search
Deopurkar R., Ghanim H., Friedman J., Abuaysheh S., Sia C.L., Mohanty P., Viswanathan P., Chaudhuri A., Dandona P. (2010) Diabetes Care, 33(5), 991–997. CrossRef Scholar google search
Mothe-Satney I., Filloux C., Amghar H., Pons C., Bourlier V., Galitzky J., Grimaldi P.A., Féral C.C., Bouloumié A., Van Obberghen E., Neels J.G. (2012) Diabetes, 61(9), 2311–2319. CrossRef Scholar google search
Kurokaw J., Nagano H., Ohara O., Kubota N., Kadowaki T., Arai S., Miyazaki T. (2011) Proc. Natl. Acad. Sci.USA., 108, 12072–12077. CrossRef Scholar google search
Yang H., Youm Y.H., Vandanmagsar B., Ravussin A., Gimble J.M., Greenway F., Stephens J.M., Mynatt R.L., Dixit V.D. (2010) J. Immunol., 185, 1836-1845. CrossRef Scholar google search
Feuerer M., Herrero L., Cipolletta D., Naaz A., Wong J., Nayer A., Lee J., Goldfine A.B., Benoist C.,Shoelson S., Mathis D. (2009) Nat. Med., 15, 930–939. CrossRef Scholar google search
Rocha V.Z., Folco E.J., Sukhova G., Shimizu K., Gotsman I., Vernon A.H., Libby P. (2008) Circ. Res., 103, 467–476. CrossRef Scholar google search
Bertola A., Ciucci T., Rousseau D., Bourlier V., Duffaut C., Bonnafous S., Blin-Wakkach C., Rodolphe A.A., Gugenheim I.J., Tran A.B., Wakkach P.G. (2012) Diabetes, 61, 2238–2247. CrossRef Scholar google search
Mandal P., Pratt B.T., Barnes M., McMullen M.R., Nagy L.E. (2011) J. Biol. Chem., 286, 13460–13469. CrossRef Scholar google search
Zamboni M., Di Francesco V., Garbin U., Fratta Pasini A., Mazzali G., Stranieri C., Zoico E., Fantin F., Bosello O., Cominacini L. (2007) Int. J. Obes. (Lond.), 31, 1104-1109. CrossRef Scholar google search
Gonzalez-Gay M.A., De Matias J.M., Gonzalez-Juanatey C., Garcia-Porrua C., Sanchez-Andrade A., Martin J., Llorca J. (2006) Clin. Exp. Rheumatol., 24, 83-86. Scholar google search
Gonzalez-Gay M.A., Gonzalez-Juanatey C., Vazquez-Rodriguez T.R., Miranda-Filloy J.A., Llorca J. (2010)Ann. N-Y Acad. Sci., 1193, 153-159. CrossRef Scholar google search
Stagakis I., Bertsias G., Karvounaris S., Kavousanaki M., Virla D., Raptopoulou A., Kardassis D., Boumpas D.T., Sidiropoulos P.I. (2012) Arthritis Res. Ther., 14, R 141. Scholar google search
Cho H., Black S.C., Looper D., Shi M., Kelly-Sullivan D., Timofeevski S., Siegel K., Yu X.H., McDonnell S.R., Chen P., Yie J., Kathleen M.O., Fraser J., Briscoe C.P. (2008) Am. J. Physiol. Endocrinol. Metab., 295, 1142–1151. CrossRef Scholar google search
Stebbins J.L., De S.K., Machleidt T., Becattini B., Vazquez J., Kuntzen C., Chen L.H., Cellitti J.F., Riel-Mehan M., Emdadi A., Solinas G., Karin M., Pellecchia M. (2008) Proc. Natl. Acad. Sci. USA, 105, 16809-16813. CrossRef Scholar google search
Ramos-Zavala M.G., González-Ortiz M., Martínez-Abundis E., Robles-Cervantes J.A., González-LYpez R., Santiago-Hernández N.J. (2011) Diabetes Care, 34, 1591–1594. Scholar google search
Pavlatou M.G., Mastorakos G., Margeli A., Kouskouni E., Tentolouris N., Katsilambros N., Chrousos G.P., Papassotiriou I. (2011) Eur. J. Clin. Invest., 41, 652–658. CrossRef Scholar google search
Fujisaka S., Usui I., Kanatani Y., Ikutani M., Takasaki I., Tsuneyama K., Tabuchi Y., Bukhari A., Yamazaki Y., Suzuki H., Senda S., Aminuddin A., Nagai Y., Takatsu K., Kobayashi M., Tobe K. (2011) Endocrinology, 152, 1789–1799. CrossRef Scholar google search
Van der Zijl N.J., Moors C.C., Goossens G.H., Blaak E.E., Diamant M. (2012) Diabetes Obes. Metab., 14, 586–595. CrossRef Scholar google search
Garcia-Guerra L., Nieto-Vazquez I., Vila-Bedmar R., Jurado-Pueyo M., Zalba G., Dhez J., Murga C., Fernández-Veled S., Mayor F. Jr., Lorenzo M. (2010) Diabetes, 59, 2407-2417. CrossRef Scholar google search
Luan B., Zhao J., Wu H., Duan B., Shu G.W., Wang X.Y., Li D., Jia W., Kang J., Pei G. (2009) Nature, 457, 1146–1150. CrossRef Scholar google search
Mayor F. Jr., Lucas E., Jurado-Pueyo M., Garcia-Guerra L., Nieto-Vazquez I., Vila-Bedmar R., Fernández-Veledo S., Murga C. (2011)Arch. Physiol. Biochem., 117, 125–130. CrossRef Scholar google search
Tuo Y., Feng D.D., Wang D.-F., Sun J., Li S.-B., Chen C. (2012) Clin. Exp. Pharmacol. Physiol., 39, 423–428. CrossRef Scholar google search
Chu Z.L., Jones R.M., He H., Carroll C., Gutierrez V., Lucman A., Moloney M., Gao H., Mondala H., Bagnol D., Unett D., Liang Y., Demarest K., Semple G., Behan D.P., Leonard J. (2007) Endocrinology, 148, 2601–2609. Scholar google search
Christensen D.P., Dahllöf M., Lundh M., Rasmussen D.N., Nielsen M.D., Billestrup N., Grunnet L.G., Mandrup-Poulsen T. (2011) Mol. Med., 17, 378–390. CrossRef Scholar google search
Lewis E.C., Blaabjerg L., Størling J., Ronn S.G., Mascagni P., Dinarello C.A., Mandrup-Poulsen T. (2011) Mol. Med., 17, 369–377. CrossRef Scholar google search
Winkler R., Benz V., Clemenz M., Bloch M., Foryst-Ludwig A., Wardat S., Witte N., Trappiel M., Namsolleck P., Mai K., Spranger J., Matthias G., Roloff T., Truee O., Kappert K., Schupp M., Matthias P., Kintscher U. (2012) Diabetes, 61, 513–523. CrossRef Scholar google search
Fuentes E., Guzmán-Jofre L., Moore-Carrasco R., Palomo I. (2013) Mol. Med. Rep., 8, 1611-1616. Scholar google search
Chiarelli F., Di Marzio D. (2008) Vasc. Health Risk. Manag., 4, 297–304. Scholar google search
Odegaard J.I., Ricardo-González R.R., Goforth M.H., Morel C.R., Subramanian V., Mukundan L., Red Eagle A., Vats D., Brombacher F., Ferrante A.W., Chawla A. (2007) Nature, 447(7148), 1116–1120. CrossRef Scholar google search
Cipolletta D., Feuerer M., Li A., Kamei N., Lee J., Shoelson S.E., Benoist C., Mathis D. (2012) Nature, 486(7404), 549–553. Scholar google search
Serhan C.N., Hong S., Gronert K., Colgan S.P., Devchand P.R., Mirick G., Moussignac R.L. (2002) J. Exp. Med., 196, 1025–1037. CrossRef Scholar google search
Clish C.B., O’Brien J.A., Gronert K., Stahl G.L., Petasis N.A., Serhan C.N. (1999) Proc. Natl. Acad. Sci. USA, 96, 8247–8252. Scholar google search
Mukherjee P.K., Marcheselli V.L., Barreiro S., Hu J., Bok D., Bazan N.G. (2007) Proc. Natl. Acad. Sci. USA, 104, 13152–13157. CrossRef Scholar google search
Titos E., Rius B., González-Périz A., LYpez-Vicario C., Morán-Salvador E., Martínez-Clemente M., Arroyo V., Clària J. (2011) J. Immunol., 187, 5408–5418. Scholar google search
González-Périz A., Horrillo R., Ferré N., Gronert K., Dong B., Morán-Salvador E., Titos E., Martínez-Clemente M., López-Parra M., Arroyo V., Clària J. (2009) FASEB J., 23, 1946–1957. CrossRef Scholar google search
Horrillo R., González-Périz A., Martínez-Clemente M., López-Parra M., Ferré N., Titos E., Morán-Salvador E., Deulofeu R., Arroyo V., Clària J. (2010) J. Immunol., 184, 3978–3987. CrossRef Scholar google search
