Concentrations of 46 proteins have been determined in human blood plasma using PlasmaDeepDive™ MRM Panel ("Biognosys AG", Switzerland). 18 of them were included into the group of proteins with higher concentrations, also identified by the shotgun proteomic analysis. Based on literature data it is concluded that the PlasmaDeepDive™ MRM Panel is applicable for studies of human plasma samples for potential biomarkers of various nervous system disorders.
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Keywords: biomarkers, mass spectrometry, pathology of the central nervous system, peptide, protein panel, quantitative proteomics
Citation:
Miroshnichenko Iu.V., Petushkova N.A., Moskaleva N.E., Teryaeva N.B., Zgoda V.G., Ilgisonis E.V., Belyaev A.Yu. (2015) The possibility of using PlasmaDeepDive™ MRM panel in clinical diagnostics. Biomeditsinskaya Khimiya, 61(2), 272-278.
Miroshnichenko Iu.V. et al. The possibility of using PlasmaDeepDive™ MRM panel in clinical diagnostics // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 2. - P. 272-278.
Miroshnichenko Iu.V. et al., "The possibility of using PlasmaDeepDive™ MRM panel in clinical diagnostics." Biomeditsinskaya Khimiya 61.2 (2015): 272-278.
Miroshnichenko, Iu. V., Petushkova, N. A., Moskaleva, N. E., Teryaeva, N. B., Zgoda, V. G., Ilgisonis, E. V., Belyaev, A. Yu. (2015). The possibility of using PlasmaDeepDive™ MRM panel in clinical diagnostics. Biomeditsinskaya Khimiya, 61(2), 272-278.
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