Bacterial recombinant L-asparaginases: properties, structure and anti-proliferative activity Sokolov N.N.1 2 1 1 1 1 3 3 1 1 1. Institute of Biomedical Chemistry, Moscow, Russia2. Centre “Bioengineering”, Russian Academy of Sciences, Moscow, Russia3. Lomonosov Moscow State University, Chemical Faculty, Moscow, Russia Section: Review DOI: 10.18097/PBMC20156103312 PubMed Id: 26215408
Year: 2015 Volume: 61 Issue : 3 Pages: 312-324in vitro . The resultant recombinant L-asparaginases (EwA, YpA, HpA и RrA) exhibit reasonable cytotoxic action on the human leukemia cells comparable to the pharmacologically available L-asparaginase EcA and represent practical interest in respect to creation, on their basis, new effective antineoplastic remedies. Further prospects of researches on bacterial L-asparaginases are associated with development of analogs of Rhodospirillum rubrum L-asparaginase (RrA) by means of directed changes of the protein structure using genetic engineering, development of chito-PEGylation for receiving L-asparaginase preparations with improved pharmacokinetic characteristics.Download PDF: Keywords: L-asparaginase, L-glutaminase, recombinant proteins, leukemia, PEGylated L-asparaginase, chito-PEGylation
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Sokolov N.N., Eldarov M.A., Pokrovskaya M.V., Aleksandrova S.S., Abakumova O.Yu., Podobed O.V., Melik-Nubarov N.S., Kudryashova E.V., Grishin D.V., Archakov A.I. (2015) Bacterial recombinant L-asparaginases: properties, structure and anti-proliferative activity. Biomeditsinskaya Khimiya, 61 (3), 312-324.
Sokolov N.N. et al. Bacterial recombinant L-asparaginases: properties, structure and anti-proliferative activity // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 3. - P. 312-324.
Sokolov N.N. et al., "Bacterial recombinant L-asparaginases: properties, structure and anti-proliferative activity." Biomeditsinskaya Khimiya 61.3 (2015): 312-324.
Sokolov, N. N., Eldarov, M. A., Pokrovskaya, M. V., Aleksandrova, S. S., Abakumova, O. Yu., Podobed, O. V., Melik-Nubarov, N. S., Kudryashova, E. V., Grishin, D. V., Archakov, A. I. (2015). Bacterial recombinant L-asparaginases: properties, structure and anti-proliferative activity. Biomeditsinskaya Khimiya , 61(3), 312-324.
This paper is also available as the English translation: 10.1134/S199075081504006X
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