Molecularly imprinted polymers in electro analysis of proteins

Shumyantseva V.V.1 , Bulko T.V.1, Baychorov I.Kh.2, Archakov A.I.3

1. Institute of Biomedical Chemistry, Moscow, Russia; IBMC-EcoBioPharm Company, Moscow, Russia
2. IBMC-EcoBioPharm Company, Moscow, Russia
3. Institute of Biomedical Chemistry, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20156103325      PubMed Id: 26215409
Year: 2015  Volume: 61  Issue: 3  Pages: 325-331
In the review the main approaches to creation of recognition materials capable of competing with biological specific receptors, (polymeric analogs of antibodies or molecularly imprinted polymers, MIP) for the electro analysis of functionally significant proteins such as a myoglobin, troponin T, albumin, human ferritin, calmodulin are considered. The main types of monomers for MIP fabrication, and methods for MIP/protein interactions, such as a surface plasmon resonance (SPR), nanogravimetry with use of the quartz crystal resonator (QCM), spectral and electrochemical methods are discussed. Experimental data on electrochemical registration of a myoglobin using MIP/electrode are presented. For a development of electrochemical sensor systems based on MIPs, o-phenylenediamine (1,2-diaminobenzene was used as a monomer. It was shown that the imprinting factor Imax(MIP)/Imax(NIP), calculated as a myoglobin signal ratio when embedding in MIP to a myoglobin signal when embedding in the polymer received without molecular template (NIP) corresponds 2-4.
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Keywords: molecularly imprinting, molecularly imprinted polymers (MIP), nanomaterials, electroanalysis, electrochemical sensors, MIP sensor, proteins

Shumyantseva, V. V., Bulko, T. V., Baychorov, I. Kh., Archakov, A. I. (2015). Molecularly imprinted polymers in electro analysis of proteins. Biomeditsinskaya Khimiya, 61(3), 325-331.
This paper is also available as the English translation: 10.1134/S1990750816020104
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