Hedgehog signaling in the pathogenesis of neuro-oncology diseases

Cherepanov S.A.1 , Baklaushev V.P.1, Gabashvili A.N.1, Shepeleva I.I.1, Chekhonin V.P.1

1. Pirogov Russian National Research Medical University, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20156103332      PubMed Id: 26215410
Year: 2015  Volume: 61  Issue: 3  Pages: 332-342
The review summarizes current knowledge on the Hedgehog signaling pathway, its role in normal embryogenesis and/or initiation and progression of neuro-oncological diseases, especially of high-grade gliomas, the most malignant neuroepithelial tumors. The main proteins forming the Hedgehog signaling pathway include Shh, PTCH1, SMO, HHIP, SUFU and GLI1 isoforms. Effects of other signaling pathways on the family of transcription factors GLI and other proteins are described. The review summarizes modern data about the impact of the Hedgehog signaling pathway on proliferation, migration activity and invasiveness, and also on tumor neoangiogenesis and tumor cell chemoresistance. The role of the Hedgehog signaling pathway in origin of cancer stem cells and epithelial-mesenchymal transition is also analyzed. Some prospects for new anticancer drugs acting on components of the Hedgehog signaling pathway inhibitors are demonstrated.
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Keywords: glioblastoma multiforme, Hedgehog signaling pathway, Shh protein, transcription factor GLI

Cherepanov, S. A., Baklaushev, V. P., Gabashvili, A. N., Shepeleva, I. I., Chekhonin, V. P. (2015). Hedgehog signaling in the pathogenesis of neuro-oncology diseases. Biomeditsinskaya Khimiya, 61(3), 332-342.
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