We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.
Zverinsky I.V., Zverinskaya H.G., Sutsko I.P., Telegin P.G., Shlyahtun A.G. (2015) Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy. Biomeditsinskaya Khimiya, 61(3), 381-383.
Zverinsky I.V. et al. Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 3. - P. 381-383.
Zverinsky I.V. et al., "Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy." Biomeditsinskaya Khimiya 61.3 (2015): 381-383.
Zverinsky, I. V., Zverinskaya, H. G., Sutsko, I. P., Telegin, P. G., Shlyahtun, A. G. (2015). Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy. Biomeditsinskaya Khimiya, 61(3), 381-383.
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