Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy

   
Zverinsky I.V.1 , Zverinskaya H.G.1, Sutsko I.P.1, Telegin P.G.1, Shlyahtun A.G.1

1. Institute of Biochemistry of Biologically Active Compounds NASB
Section: Experimental Study
DOI: 10.18097/PBMC20156103381      UDK: 615.362+577.158(611.36)      PubMed Id: 26215416
Year: 2015  Volume: 61  Issue: 3  Pages: 381-383
We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.
Download PDF:
Reference:

Zverinsky I.V., Zverinskaya H.G., Sutsko I.P., Telegin P.G., Shlyahtun A.G. (2015) Biomeditsinskaya khimiya, 61(3), 381-383.
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)
        

© Institute of Biomedical Chemistry, Moscow, Russia