Extracellular nucleic acids (exNA) were described in blood of both healthy and illness people as early as in 1948, but staied overlooked until middle 60-th. Starting from the beginning of new millennium and mainly in the last 5 years exNA are intensively studied. Main attention is directed to investigation of exNA as the source of diagnostic material whereas the mechanisms of their generation, as well as mechanisms to providing long-term circulation of exNA in the bloodstream are not established unambiguously. According to some authors, the main source of circulating nucleic acids in blood are the processes of apoptosis and necrosis, while others refer to the possible nucleic acid secretion by healthy and tumor cells. Circulating DNA were found to be stable in the blood for a long time, escaping from the action of DNA hydrolyzing enzymes and are apparently packed in different supramolecular complexes. This review presents the opinions of various authors and evidence in favor of all the theories describingappearance of extracellular DNA, the features of the circulation and structure of the extracellular DNA and factors affecting the time of DNA circulation in blood
Download PDF:
Keywords: circulating DNA, apoptosis, necrosis, oncosis, active secretion, Dnase
Citation:
Bryzgunova O.E., Laktionov P.P. (2015) Generation of blood circulating DNA: the sources, peculiarities of circulation and structure. Biomeditsinskaya Khimiya, 61(4), 409-426.
Bryzgunova O.E. et al. Generation of blood circulating DNA: the sources, peculiarities of circulation and structure // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 4. - P. 409-426.
Bryzgunova O.E. et al., "Generation of blood circulating DNA: the sources, peculiarities of circulation and structure." Biomeditsinskaya Khimiya 61.4 (2015): 409-426.
Bryzgunova, O. E., Laktionov, P. P. (2015). Generation of blood circulating DNA: the sources, peculiarities of circulation and structure. Biomeditsinskaya Khimiya, 61(4), 409-426.
Tan E., Schur P., Carr R., Kunkel H. (1966) J. Clin. Invest., 45, 1732-1740. Scholar google search
Tamkovich S., Laktionov P., Rykova E., Starikov A., Skvortsova T., Kuznetsova N., Permyakova V., Vlasov V. (2005) Byull. eksp. biol. med. 139, 462-464. Scholar google search
Silva J., Dominguez G., Garcia J., Gonzalez R., Villanueva M., Navarro F., Provencio M., San Martin S., Espaca P., Bonilla F. (1999) Cancer Res., 59, 3251-3256. Scholar google search
Roupret M., Hupertan V., Catto J., Yates D., Rehman I., Proctor L., Phillips J., Meuth M., Cussenot O., Hamdy F. (2008) Int. J. Cancer., 122, 952-956. CrossRef Scholar google search
Jahr S., Hentze H., Englisch S., Hardt D., Fackelmayer F., Hesch R., Knippers R. (2001) Cancer Res., 61, 1659-1665. Scholar google search
Ludovini V., Pistola L., Gregorc V., Floriani I., Rulli E., Piattoni S., Di Carlo L., Semeraro A., Darwish S., Tofanetti F. et al. (2008) J. Thorac. Oncol., 3, 365-373. CrossRef Scholar google search
Ellinger J., Bastian P., Haan K., Heukamp L., Buettner R., Fimmers R., Mueller S., Ruecker A. (2008) Int. J. Cancer, 122, 138-143. CrossRef Scholar google search
Chia D., Dorsch C., Levy L., Barnett E. (1979) Immunology, 36, 323-329. Scholar google search
Lau T., Leung T., Chan L., Lau T., Chan K., Tam W., Lo Y. (2002) Clin. Chem., 48, 2141-2146. Scholar google search
Cherepanova A., Tamkovich S., Pyshnyi D., Kharkova M., Vlassov V., Laktionov P. (2007) J. Immunol. Methods, 325, 96-103. CrossRef Scholar google search
Holdenrieder S., Stieber P., Bodenmuller H., Busch M., Fertig G., Furst H., Schalhorn A., Schmeller N., Untch M., Seidel D. (2001) Int. J. Cancer, 95, 114-120. CrossRef Scholar google search
Holdenrieder S., Nagel D., Schalhorn A., Heinemann V., Wilkowski R., Pawel J., Raith H., Feldmann K., Kremer A., Muller S., Geiger S., Hamann G., Seidel D., Stieber P. (2008) Ann. N.-Y. Acad. Sci., 1137, 180-189. CrossRef Scholar google search
Kiroi K., Tanaka C., Toi M. (2001) Int. J. Oncol., 19, 143-148. Scholar google search
Martelli A., Zweyer M., Ochs R., Tazzari P., Tabellini G., Narducci P., Bortul R. (2001) J. Cell. Biochem., 82, 634-646. CrossRef Scholar google search
Morozkin E., Loseva E., Morozov I., Kurilshikov A., Bondar A., Rykova E., Rubtsov N., Vlassov V., Laktionov P. (2012) Expert Opin. Biol. Ther., 12, S11-S17. CrossRef Scholar google search
Bickerstaff M., Botto M., Hutchinson W., Herber J., Tennent G., Bybee A., Mitchell D., Cook H., Butler P., Walport M., Pepys M. (1999) Nat. Med., 5, 694-697. CrossRef Scholar google search
Egorova V.A., Blinov M.N., DNA-binding blood proteins in hemoblastoses, Voprosy meditsinskoi khimii, 1993, vol: 39(3), 36-38. Scholar google search
Beltinger C., Saragovi H., Smith R., LeSauteur L., Shah N., DeDionisio L., Christensen L., Raible A., Jarett L., Gewirtz A. (1995) J. Clin. Invest., 95, 1814-1823. CrossRef Scholar google search
Gasparro F., Dall’Amico R., O’Malley M., Heald P., Edelson R. (1990) Photochem. Photobiol., 52, 315-321. Scholar google search
Morozkin E., Laktionov P., Rykova E., Vlassov V. (2004) Ann. N.-Y. Acad. Sci., 1022, 244-249. CrossRef Scholar google search
Skvortsova T., Rykova E., Tamkovich S., Bryzgunova O., Starikov A., Kuznetsova N., Vlassov V., Laktionov P. (2006) Br. J. Cancer., 94, 1492-1495. CrossRef Scholar google search
Laktionov P., Tamkovich S., Rykova E., Bryzgunova O., Starikov A., Kuznetsova N., Vlassov V. (2004) Ann. N.-Y. Acad. Sci., 1022, 221-227. CrossRef Scholar google search
Kolesnikova E., Tamkovich S., Bryzgunova O., Shelestyuk P., Permyakova V., Vlassov V., Tuzikov A., Laktionov P., Rykova E. (2008) Ann. N.-Y. Acad. Sci., 1137, 226-231. CrossRef Scholar google search
Tamkovich S., Bryzgunova O., Rykova E., Permyakova V., Vlassov V., Laktionov P. (2005) Clin. Chem., 51, 1317-1319. CrossRef Scholar google search
Tamkovich S.N., Bryzgunova O.E., Rykova E.Yu., Kolesnikova E.V., Shelestuk P.I., Laktionov P.P., Vlassov V.V., Circulating nucleic acids in blood of patients with malignant tumors of gastrointestinal tract, Biomeditsinskaya khimiya, 2005, vol: 51(3), 321-328. Scholar google search
Tamkovich S., Laktionov P., Bryzgunova O., Starikov A., Rykova E., Kuznetsova N., Permyakova V., Vlasov V. (2005) Mol. med., 2, 46-50. Scholar google search
Hefeneider S., Cornell K., Brown L., Bakke A., McCoy S., Bennett R. (1992) Clin. Immunol. Immunopathol., 63, 245-251. CrossRef Scholar google search
Koutouzov S., Cabrespines A., Amoura Z., Chabre H., Lotton C., Bach J. (1996) Eur. J. Immunol., 26, 472-486. CrossRef Scholar google search
Beau-Faller M., Gaub M., Schneider A., Ducrocq X., Massard G., Gasser B., Chenard M., Kessler R., Anker P., Stroun M., Weitzenblum E., Pauli G., Wihlm J., Quoix E., Oudet P. (2003) Int. J. Cancer, 105, 361-370. CrossRef Scholar google search
Chen X., Stroun M., Magnenat J., Nicod L., Kurt A., Lyautey J., Lederrey C., Anker P. (1996) Nat. Med., 2, 1033-1035. CrossRef Scholar google search
Perego R., Corizzato M., Brambilla P., Ferrero S., Bianchi C., Fasoli E., Signorini S., Torsello B., Invernizzi L., Bombelli S. et al. (2008) Eur. J. Cancer., 44, 1039-1047. CrossRef Scholar google search
Van Tilborg A., Kompier L., Lurkin I., Poort R., Bouazzaoui S., Keur K., Zuiverloon T., Dyrskjot L., Orntoft T., Roobol M. (2012) PLoS One, 7, e43345. CrossRef Scholar google search
Muller I., Beeger C., Alix-Panabieres C., Rebillard X., Pantel K., Schwarzenbach H. (2008) Clin. Chem., 54, 688-696. CrossRef Scholar google search
Sunami E., Shinozaki M., Higano C., Wollman R., Dorff T., Tucker S., Martinez S., Singer F., Hoon D. (2009) Clin. Chem., 55, 559-567. CrossRef Scholar google search
Chang Y., Ho C., Chen H., Chang T., Lai W., Dai Y., Lee W., Chow N. (2002) Br. J. Cancer, 87, 1449-1453. CrossRef Scholar google search
Chen X., Bonnefoi H., Diebold-Berger S., Lyautey J., Lederrey C., Faltin-Traub E., Stroun M., Anker P. (1999) Clin. Cancer Res., 5, 2297-2303. Scholar google search
von Knobloch R., Hegele A., Brandt H., Varga Z., Wille S., Kalble T., Heidenreich A., Hofmann R. (2002) Int. J. Cancer, 98, 889-894. CrossRef Scholar google search
Schwarzenbach H., Alix-Panabieres C., Muller I., Letang N., Vendrell J., Rabillard X., Pantel K. (2009) Clin. Cancer Res., 15, 1032-1038. CrossRef Scholar google search
Li J., Harris L., Mamon H., Kulke M., Liu W., Zhu P., Makrigiorgos M. (2006) J. Mol. Diagn., 8, 22-30. CrossRef Scholar google search
Sozzi G., Musso K., Ratcliffe C., Goldstraw P., Pierotti M., Pastorino U. (1999) Clin. Cancer Res., 5, 2689-2692. Scholar google search
Fujiwara Y., Chi D., Wang H., Keleman P., Morton D., Turner R., Hoon D. (1999) Cancer Res., 59, 1567-1571. Scholar google search
Taback B., Fujiwara Y., Wang H., Foshag L., Morton D., Hoon D. (2001) Cancer Res., 61, 5723-5726. Scholar google search
Taback B., O'Day S., Boasberg P., Shu S., Fournier P., Elashoff R., Wang H., Hoon D. (2004) J. Natl. Cancer Inst., 96, 152-156. Scholar google search
Eisenberger C., Schoenberg M., Enger C., Hortopan S., Shah S., Chow N., Marshall F., Sidransky D. (1999) J. Natl. Cancer Inst., 91, 2028-2032. CrossRef Scholar google search
Gonzalgo M., Eisenberger C., Lee S., Trock B., Marshall F., Hortopan S., Sidransky D., Schoenberg M. (2002) Clin. Cancer Res., 8, 1878-1881. Scholar google search
Dominguez G., Carballido J., Silva J., Silva J., Garcia J., Menendez J., Provencio M., Espana P., Bonilla F. (2002) Clin. Cancer Res., 8, 980-985. Scholar google search
Goto K., Ichinose Y., Ohe Y., Yamamoto N., Negoro S., Nishio K., Itoh Y., Jiang H., Duffield E., McCormack R., Saijo N., Mok T., Fukuoka M. (2012) J. Thorac. Oncol., 7, 115-121. CrossRef Scholar google search
Taniguchi K., Uchida J., Nishino K., Kumagai T., Okuyama T., Okami J., Higashiyama M., Kodama K., Imamura F., Kato K. (2011) Clin. Cancer Res., 17, 7808-7815. CrossRef Scholar google search
Ramirez J., Sarries C., de Castro P., Roig B., Queralt C., Escuin D., de Aguirre I., Sanchez J., Manzano J., Margeli M., Sanchez J., Astudillo J., Taron M., Rosell R. (2003) Cancer Lett., 193, 207-216. CrossRef Scholar google search
Hayashi T., Sugahara K., Dateki N., Yamada Y., Sudou R., Kanematsu T., Kamihira S. (2000) Rinsho. Byori., 48, 547-553. Scholar google search
Andriani F., Conte D., Mastrangelo T., Leon M., Ratcliffe C., Roz L., Pelosi G., Goldstraw P., Sozzi G., Pastorino U. (2004) Int. J. Cancer., 108, 91-96. CrossRef Scholar google search
Gonzalez R., Silva J., Sanchez A., Dominguez G., Garcia J., Chen X., Stroun M., Provencio M., Espana P., Anker P., Bonilla F. (2000) Ann. Oncol., 11, 1097-1104. CrossRef Scholar google search
Swisher E., Wollan M., Mahtani S., Willner J., Garcia R., Goff B., King M. (2005) Am. J. Obstet. Gynecol., 193, 662-667. CrossRef Scholar google search
Su P., Zhang L., Wan W., Ren H., Zhang G., Wang Y., Deng G., Ji J. (2005) Beijing Da Xue Xue Bao., 37, 523-526. Scholar google search
Wang J., Hsieh J., Chen C., Tzou W., Cheng T., Chen F., Huang T., Huang Y., Huang S., Yang T., Lin S. (2004) J. Surg. Res., 120, 242–248. CrossRef Scholar google search
Wang Y., Yamaguchi Y., Watanabe H., Ohtsubo K., Motoo Y., Sawabu N. (2004) Pancreas, 28, 13-19. Scholar google search
Ito T., Kaneko K., Makino R., Konishi K., Kurahashi T., Ito H., Katagiri A., Kushima M., Kusano M., Mitamura K., Imawari M. (2003) Oncol. Rep., 10, 1937-1942. Scholar google search
Hibi K., Robinson C., Booker S., Wu L., Hamilton S., Sidransky D., Jen J. (1998) Cancer Res., 58, 1405-1407. Scholar google search
Kimbi G., Kew M., Yu M., Arakawa K., Hodkinson J. (2005) J. Gastroenterol. Hepatol., 20, 1185-1190. Scholar google search
Kirk G., Lesi O., Mendy M., Szymacska K., Whittle H., Goedert J., Hainaut P., Montesano R. (2005) Oncogene, 24, 5858-5867. Scholar google search
Di G., Liu G., Wu J., Shen Z., Shao Z. (2003) Zhonghua Zhong. Liu. Za. Zhi., 25, 137-140. Scholar google search
Ling E., Fich A., Man S., Wolfson M., Mikhailowsky R., Lamprecht S. (2000) In Vivo, 14, 543-546. Scholar google search
Sorensen B., Mortensen L., Andersen J., Nexo E. (2010) Anticancer Res., 30, 2463-2468. Scholar google search
Combaret V., Audoynaud C., Iacono I., Favrot M., Schell M., Bergeron C., Puisieux A. (2002) Cancer Res., 62, 3646-3648. Scholar google search
Perkins R., Sahm K., Marando C., Dickson-Witmer D., Pahnke G., Mitchell M., Petrelli N., Berkowitz I., Soteropoulos P., Aris V., Dunn S., Krueger L. (2006) Breast Cancer Res., 8, R70. CrossRef Scholar google search
Liang J., Xu A., Xie Y., Awonuga A., Lin Z. (2008) Cancer Gen. Cytogen., 95, e100. Scholar google search
Lo Y., Chan L., Lo K., Leung S., Zhang J., Chan A., Lee J., Hjelm N., Johnson P., Huang D. (1999) Cancer Res., 59, 1188-1191. Scholar google search
Dong S., Pai S., Rha S., Hildesheim A., Kurman R., Schwartz P., Mortel R., McGowan L., Greenberg M., Barnes W., Sidransky D. (2002) Cancer Epidemiol. Biomarkers Prev., 11, 3-6. Scholar google search
Zachariah R., Schmid S., Buerki N., Radpour R., Holzgreve W., Zhong X. (2008) Obstet. Gynecol., 112, 843-850. CrossRef Scholar google search
Mehra N., Penning M., Maas J., van Daal N., Giles R., Voest E. (2007) Clin. Cancer Res., 13, 421-426. CrossRef Scholar google search
Jeronimo C., Nomoto S., Caballero O., Usadel H., Henrique R., Varzim G., Oliveira J., Lopes C., Fliss M., Sidransky D. (2001) Oncogene, 20, 5195-5198. CrossRef Scholar google search
Hoque M., Feng Q., Toure P., Dem A., Critchlow C., Hawes S., Wood T., Jeronimo C., Rosenbaum E., Stern J., Yu M., Trink B., Kiviat N., Sidransky D. (2006) J. Clin. Oncol., 24, 4262-4269. CrossRef Scholar google search
Wong I., Lo Y., Zhang J., Liew C., Ng M., Wong N., Lai P., Lau W., Hjelm N., Johnson P. (1999) Cancer Res., 59, 71-73. Scholar google search
Chang H., Yi B., Li L., Zhang H., Sun F., Dong S., Cao Y. (2008) Exp. Mol. Pathol., 85, 96-100. CrossRef Scholar google search
Ibanez de Caceres I., Battagli C., Esteller M., Herman J., Dulaimi E., Edelson M., Bergman C., Ehya H., Eisenberg B., Cairns P. (2004) Cancer Res., 64, 6476-6481. CrossRef Scholar google search
Dulaimi E., Hillinck J., Ibanez de Caceres I., Al-Saleem T., Cairns P. (2004) Clin. Cancer Res., 10, 6189-6193. CrossRef Scholar google search
Wang T., Pan Q., Lin Li., Szulwach K., Song C., He C., Wu H., Warren S., Jin P., Duan R., Li X. (2012) Hum. Mol. Genet., 21, 5500-5510. CrossRef Scholar google search
Hendrich B., Abbott C., McQueen H., Chambers D., Cross S., Bird A. (1999) Mamm. Genome, 10, 906-912. CrossRef Scholar google search
Hashimoto H., Liu Y., Upadhyay A., Chang Y., Howerton S., Vertino P., Zhang X., Cheng X. (2012) Nucl. Acids Res., 40, 4841-4849. CrossRef Scholar google search
Lin J., Jeong S., Liang G., Takai D., Fatemi M., Tsai Y., Egger G., Gal-Yam E., Jones P. (2007) Cancer Cell., 12, 432-444. CrossRef Scholar google search
Prokhortchouk A., Hendrich B., Jorgensen H., Ruzov A., Wilm M., Georgiev G., Bird A., Prokhortchouk E. (2001) Genes Dev., 15, 1613-1618. CrossRef Scholar google search
Filion G., Zhenilo S., Salozhin S., Yamada D., Prokhortchouk E., Defossez P. (2006) Mol. Cell. Biol., 26, 169-181. CrossRef Scholar google search
Majumder S., Kutay H., Datta J., Summers D., Jacob S., Ghoshal K. (2006) J. Cell. Biochem., 97, 1300-1316. CrossRef Scholar google search
Martens J., O'Sullivan R., Braunschweig U., Opravil S., Radolf M., Steinlein P., Jenuwein T. (2005) EMBO J., 24, 800-812. CrossRef Scholar google search
Pan C., Sinicropi D., Lazarus R. (2001) Methods Mol. Biol., 160, 309-321. Scholar google search
Galeazzi M., Morozzi G., Piccini M., Chen J., Bellisai F., Fineschi S., Marcolongo R. (2003) Autoimmunity Rev., 2, 50-55. CrossRef Scholar google search
Martinez-Valle F., Balada E., Ordi-Ros J., Bujan-Rivas S., Sellas-Fernandez A., Vilardell-Tarres M. (2009) Lupus, 18, 418-423. CrossRef Scholar google search
Bodano A., Gonzalez A., Ferreiros-Vidal I., Balada E., Ordi J., Carreira P., Gomez-Reino J., Conde C. (2006) Rheumatology, 45, 819-823. CrossRef Scholar google search
Sallai K., Nagy E., Derfalvy B., Muzes G., Gergely P. (2005) Clin. Diagn. Lab. Immunol., 12, 56-59. Scholar google search
Frittitta L., Camastra S., Baratta R., Costanzo B., D'Adamo M., Graci S., Spampinato D., Maddux B., Vigneri R., Ferrannini E., Trischitta V. (1999) J. Clin. Endocrinol. Metab., 84, 3620-3625. Scholar google search
Baranovskii A., Ershova N., Buneva V., Kanyshkova T., Mogelnitskii A., Doronin B., Boiko A., Gusev E., Favorova O., Nevinsky G. (2001) Immunol. Lett., 76, 163-167. CrossRef Scholar google search
Shuster A., Gololobov G., Kvashuk O., Bogomolova A., Smirnov I., Gabibov A. (1992) Science, 256, 665-667. CrossRef Scholar google search
Buneva V., Kudryavtseva A., Gal'vita A., Dubrovskaya V., KHokhlova O., Kalinina I., Galenok V., Nevinskiy G. (2003) Biokhimiya, 68, 1088-1100. Scholar google search
Thuijls G., Derikx J., Prakken F., Huisman B., van Bijnen Ing A., van Heurn E., Buurman W., Heineman E. (2011) Am. J. Emerg. Med., 29, 256-260. CrossRef Scholar google search
Lim R., Lappas M., Riley C., Borregaard N., Moller H., Ahmed N., Rice G. (2013) J. Ovarian. Res., 6, 5. CrossRef Scholar google search
Sands H., Gorey-Feret L., Cocuzza A., Hobbs F., Chidester D., Trainor G. (1994) Mol. Pharm., 45, 932-943. Scholar google search
Botezatu I., Serdyuk O., Potapova G., Shelerov V., Alechina R., Molyaka Y., Anan’ev V., Bazin I., Garin A., Narimanov M., Knysh V., Melkonyan H., Umansky S., Lichtenstein A. (2000) Clin. Chem., 46, 1078-1084. Scholar google search
