Genetic and biochemical mechanisms of involvement of antioxidant defense enzymes in the development of bronchial asthma

   
Polonikov A.V.1 , Ivanov V.P.1, Bogomazov A.D.1 , Solodilova M.A.1

1. Kursk State Medical University, Kursk, Russia
Section: Review
DOI: 10.18097/PBMC20156104427      PubMed Id: 26350733
Year: 2015  Volume: 61  Issue: 4  Pages: 427-439
In the present review we have analyzed and summarized recent literature data on genetic and biochemical mechanisms responsible for involvement of antioxidant defense enzymes in the etiology and pathogenesis of bronchial asthma. It has been shown that the mechanisms of asthma development are linked with genetically determined abnormalities in the functioning of antioxidant defense enzymes. These alterations are accompanied by a systemic imbalance between oxidative and anti-oxidative reactions with the shift of the redox state toward increased free radical production and oxidative stress, a key element in the pathogenesis of bronchial asthma
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Keywords: bronchial asthma, etiology and pathogenesis, biochemical abnormalities, free radical processes, oxidative stress, antioxidant defense enzymes, genetic polymorphism
Citation:

Polonikov, A. V., Ivanov, V. P., Bogomazov, A. D., Solodilova, M. A. (2015). Genetic and biochemical mechanisms of involvement of antioxidant defense enzymes in the development of bronchial asthma. Biomeditsinskaya khimiya, 61(4), 427-439.
This paper is also available as the English translation: 10.1134/S1990750814040076
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