Biological activity of selenorganic compounds at heavy metal salts intoxication

Rusetskaya N.Y.1 , Borodulin V.B.1

1. Razumovskiy Saratov State Medical University, Saratov, Russia
Section: Review
DOI: 10.18097/PBMC20156104449      PubMed Id: 26350735
Year: 2015  Volume: 61  Issue: 4  Pages: 449-461
Possible mechanisms of the antitoxic action of organoselenium compounds in heavy metal poisoning have been considered. Heavy metal toxicity associated with intensification of free radical oxidation, suppression of the antioxidant system, damage to macromolecules, mitochondria and the genetic material can cause apoptotic cell death or the development of carcinogenesis. Organic selenium compounds are effective antioxidants during heavy metal poisoning; they exhibit higher bioavailability in mammals than inorganic ones and they are able to activate antioxidant defense, bind heavy metal ions and reactive oxygen species formed during metal-induced oxidative stress. One of promising organoselenium compounds is diacetophenonyl selenide (DAPS-25), which is characterized by antioxidant and antitoxic activity, under conditions including heavy metal intoxication
Download PDF:
Keywords: heavy metals, selen, selenorganic compounds, antitoxic activity, diacetophenonylselenide (DAPS-25)

Rusetskaya, N. Y., Borodulin, V. B. (2015). Biological activity of selenorganic compounds at heavy metal salts intoxication. Biomeditsinskaya khimiya, 61(4), 449-461.
This paper is also available as the English translation: 10.1134/S1990750815010072
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)