The nanowire (NW) detection is one of fast-acting and high-sensitive methods allowing to reveal potentially relevant protein molecules. A NW biosensor based on the silicon-on-insulator (SOI)-structures was used for biospecific label-free detection of NFAT 1 (D-NFAT 1) oncomarker in real time. For this purpose, SOI-nanowires (NWs) were modified with aptamers against NFAT 1 used as molecular probes. It was shown that using this biosensor it is possible to reach the sensitivity of ~10-15 M. This sensitivity was comparable with that of the NW biosensor with immobilized antibodies used as macromolecular probes. The results demonstrate promising approaches used to form the sensor elements for high-sensitive disease diagnostics
Malsagova K.A. et al. SOI-nanowire biosensor for the detection of D-NFAT 1 protein // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 4. - P. 462-467.
Malsagova K.A. et al., "SOI-nanowire biosensor for the detection of D-NFAT 1 protein." Biomeditsinskaya Khimiya 61.4 (2015): 462-467.
Malsagova, K. A., Ivanov, Yu. D., Pleshakova, T. O., Kozlov, A. F., Krohin, N. V., Kaysheva, A. L., Shumov, I. D., Popov, V. P., Naumova, O. V., Fomin, B. I., Nasimov, D. A. (2015). SOI-nanowire biosensor for the detection of D-NFAT 1 protein. Biomeditsinskaya Khimiya, 61(4), 462-467.
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