SOI-nanowire biosensor for the detection of D-NFAT 1 protein

   
Malsagova K.A.1, Ivanov Yu.D.1, Pleshakova T.O.1, Kozlov A.F.1, Krohin N.V.1, Kaysheva A.L.1, Shumov I.D.1 , Popov V.P.2, Naumova O.V.2, Fomin B.I.2, Nasimov D.A.2

1. Institute of Biomedical Chemistry, Moscow, Russia
2. Rzhanov Institute of Semiconductor Physics, Novosibirsk, Russia
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20156104462      PubMed Id: 26350736
Year: 2015  Volume: 61  Issue: 4  Pages: 462-467
The nanowire (NW) detection is one of fast-acting and high-sensitive methods allowing to reveal potentially relevant protein molecules. A NW biosensor based on the silicon-on-insulator (SOI)-structures was used for biospecific label-free detection of NFAT 1 (D-NFAT 1) oncomarker in real time. For this purpose, SOI-nanowires (NWs) were modified with aptamers against NFAT 1 used as molecular probes. It was shown that using this biosensor it is possible to reach the sensitivity of ~10-15 M. This sensitivity was comparable with that of the NW biosensor with immobilized antibodies used as macromolecular probes. The results demonstrate promising approaches used to form the sensor elements for high-sensitive disease diagnostics
Download PDF:
Keywords: aptamer, biosensor, D-NFAT 1, silicon-on-insulator, nanowires
Citation:

Malsagova, K. A., Ivanov, Yu. D., Pleshakova, T. O., Kozlov, A. F., Krohin, N. V., Kaysheva, A. L., Shumov, I. D., Popov, V. P., Naumova, O. V., Fomin, B. I., Nasimov, D. A. (2015). SOI-nanowire biosensor for the detection of D-NFAT 1 protein. Biomeditsinskaya khimiya, 61(4), 462-467.
This paper is also available as the English translation: 10.1134/S199075081403010X
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)