The selective toxic effect of dialdehyde derivatives of the pyrimidine nucleosides on human tumor cells

   
Efremova A.S.1, Shram S.I.1 , Drenichev M.S.2, Posypanova G.A.3, Myasoedov N.F.1, Mihaylov S.N.2

1. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
2. Engelhardt Institute of Molecular Biology, Moscow, Russia
3. Moscow Research Institute of Medical Ecology, Moscow, Russia
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20156104497      PubMed Id: 26350741
Year: 2015  Volume: 61  Issue: 4  Pages: 497-502
The impact of a number of synthetic nucleoside derivatives on the growth and survival of cultured human ovarian tumor cells (line SKOV-3) and normal human lung fibroblasts was investigated. It was shown that the dialdehyde derivatives of uridine, 1--D-eritrofuranozyl uracil and 3-O--D-ribofuranosyl-2-deoxythymidine, in contrast to their unoxidized counterparts, exert marked toxic effect on SKOV-3 cells. Cultured human fibroblasts were less susceptible to the damaging effect of the dialdehyde nucleosides. The dialdehyde derivative of 1--D-eritrofuranozyl uracil demonstrated greatest differences in the cytotoxic effect on these cultures: inhibition of tumor SKOV-3 cells growth on 50% or more was achieved at the concentrations of this compound ten times lower than in the case of normal fibroblasts.
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Keywords: dialdehyde derivatives of nucleosides, cytotoxicity, antitumor action, SKOV3 human ovarian carcinoma cell line, human fibroblasts
Citation:

Efremova, A. S., Shram, S. I., Drenichev, M. S., Posypanova, G. A., Myasoedov, N. F., Mihaylov, S. N. (2015). The selective toxic effect of dialdehyde derivatives of the pyrimidine nucleosides on human tumor cells. Biomeditsinskaya khimiya, 61(4), 497-502.
This paper is also available as the English translation: 10.1134/S1990750814040027
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