Nitric oxide and electrogenic metals (Ca, Na, K) in epidermal cells

Petukhov V.I.1 , Baumane L.K.2, Dmitriev E.V.3, Vanin A.F.4

1. Baltic Institute of Psychology, Riga, Latvia
2. Latvian Institute of Organic Synthesis, Riga, Latvia
3. Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia
4. A.Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20156104503      PubMed Id: 26350742
Year: 2015  Volume: 61  Issue: 4  Pages: 503-509
Using atomic emission spectrometry and EPR analysis metal-ligand homeostasis (MLH) has been studied in epidermal cells of 954 liquidators of the Chernobyl accident and 947 healthy individuals. A possible association of the redox status with the quantitative changes in the MLH, which could be used as discriminators of oxidative/nitrosative stress, attracts special interest. Characteristic features of oxidative stress mainly related to electrogenic metals (Ca, K, Na), were found not only among the liquidators examined, but also in some healthy individuals (18.1%); this suggests the presence of oxidative/nitrosative stress of non-radiation origin. Correlation between intracellular production of nitric oxide (NO) with quantitative changes in the electrogenic metals may indicate the possible involvement of NO in the generation of an electric potential of the cell
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Keywords: nitric oxide, metal-ligand homeostasis, redox status, epidermis

Petukhov, V. I., Baumane, L. K., Dmitriev, E. V., Vanin, A. F. (2015). Nitric oxide and electrogenic metals (Ca, Na, K) in epidermal cells. Biomeditsinskaya Khimiya, 61(4), 503-509.
This paper is also available as the English translation: 10.1134/S1990750814040064
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