Influence of gravity discharge on the content of isatin-binding proteins in mice: results of ground-based and space research under the program Bion-M №1

   
Ivanov A.S.1 , Medvedev A.E.1, Buneeva O.A.1, Gnedenko O.V.1, Ershov P.V.1, Mezencev Y.V.1, Yablokov E.O.1, Kaluzhsky L.A.1, Florinskaya A.V.1, Moskaleva N.E.1, Zgoda V.G.1

1. Institute of Biomedical Chemistry, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20156105632      PubMed Id: 26539872
Year: 2015  Volume: 61  Issue: 5  Pages: 632-635
Isatin-binding activity of mice liver proteins has been investigated in the samples from the control and flight groups by using the methods of biosensor and proteomic analysis. It was found the higher isatin-binding activity in mice of flight group. The content of a number of individual isatin-binding proteins in the samples of the flight groups differ slightly from the ground control. However, in samples from animals which have weekly post-flight adaptation, the level of certain proteins was significantly increased. The latter allows us to assume that the main events in the proteome of mice (at least in subproteome of isatin-binding proteins), occurs in early post-flight period.
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Keywords: gravitational unloading, Bion (satellite), mice, proteome, isatin-binding proteins, biosensors, mass spectrometry
Citation:

Ivanov, A. S., Medvedev, A. E., Buneeva, O. A., Gnedenko, O. V., Ershov, P. V., Mezencev, Y. V., Yablokov, E. O., Kaluzhsky, L. A., Florinskaya, A. V., Moskaleva, N. E., Zgoda, V. G. (2015). Influence of gravity discharge on the content of isatin-binding proteins in mice: results of ground-based and space research under the program Bion-M №1. Biomeditsinskaya Khimiya, 61(5), 632-635.
This paper is also available as the English translation: 10.1134/S1990750816030045
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