1. Volgograd State Medical University, Volgograd, Russia; Volgograd Medical Research Center, Volgograd, Russia 2. Volgograd State Medical University, Volgograd, Russia 3. Institute of Physical and Organic Chemistry, South Federal University, Rostov-on-Don, Russia
Pharmacokinetic properties of imidazobenzimidazole derivative compound RU-1205 were investigated after subcutaneous administration to rabbits as a substance and a dosage form (lyophilisates for injection) at a dose of 25 mg/kg. The lyophilisate was characterized by high values of the relative bioavailability. In tests, the “hot plate” and “vinegar cramps” the dosage form and the substance exhibited the same analgesic effect.
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Keywords: pharmacokinetics, pharmacodinamics, analgesia, compound RU-1205, benzimidazols, injection dosage form
Citation:
Spasov A.A., Smirnova L.A., Grechko O.U., Raschenko A.I., Shtareva D.M., Anisimova V.A. (2015) Pharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity. Biomeditsinskaya Khimiya, 61(5), 636-639.
Spasov A.A. et al. Pharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 5. - P. 636-639.
Spasov A.A. et al., "Pharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity." Biomeditsinskaya Khimiya 61.5 (2015): 636-639.
Spasov, A. A., Smirnova, L. A., Grechko, O. U., Raschenko, A. I., Shtareva, D. M., Anisimova, V. A. (2015). Pharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity. Biomeditsinskaya Khimiya, 61(5), 636-639.
References
Savage S.R., Kirsh K.L., Passik S.D. (2008) Addiction Science Clinical Practice, 4(2), 4-25. Scholar google search
Bagheri S.C. (2014) Clinical Review of Oral and Maxillofacial Surgery, 49-52. Scholar google search
Manchikanti L., Abdi S., Atluri S. et al. (2012) Pain physician, 15(3 Suppl.), S67-S116. Scholar google search
Brennan F., Carr D.B., Cousins M. (2007) Anesthesia Analgesia, 109, 208-209. Scholar google search
