Renalase is a recently discovered secretory protein, which plays a certain (still poorly understood) role in regulation of blood pressure. The review summarizes own and literature data accumulated since the first publication on relanase (2005). Initial reports on FAD-dependent amine oxidase activity of this protein were not confirmed in independent experiments performed in different laboratories. In addition, proposed amine oxidase activity of circulating extracellular renalase requires the presence of FAD, which has not been detected either in blood or urinary renalase. Moreover, renalase excreted into urine lacks its N-terminal peptide, which is ultimately needed for accommodation of the FAD cofactor. Results of the Aliverti’s group on NAD(P)H binding by renalase and weak diaphorase activity of this protein stimulated further studies of renalase as NAD(P)H oxidase catalyzing reaction of catecholamine co-oxidation. However, physiological importance of such extracellular catecholamine-metabolizing activity (demonstrated in one laboratory and not detected in another laboratory) remains unclear due to existence of much more active enzymatic systems (e.g. neutrophil NAD(P)H oxidase, xanthine oxidase/xanthine) in circulation, which can perform such co-oxidation reactions. Recently a-NAD(P)H oxidase/anomerase activity of renalase, which also pomotes oxidative conversion of b-NADH isomers inhibiting activity of NAD-dependent dehydrogenases, has been described. However, itspossible contribution tothe antihypertensive effect ofrenalase remains unclear. Thus, theantihypertensive effect of renalase still remains a phenomenon with unclear biochemical mechanim(s) and functions of intracellular and extracellular (circulating) renalases obviously differ.
Severina I.S., Fedchenko V.I., Veselovsky A.V., Medvedev A.E. (2015) The history of renalase from amine oxidase to alpha-NAD(P)H-oxidase/anomerase. Biomeditsinskaya Khimiya, 61(6), 667-679.
Severina I.S. et al. The history of renalase from amine oxidase to alpha-NAD(P)H-oxidase/anomerase // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 6. - P. 667-679.
Severina I.S. et al., "The history of renalase from amine oxidase to alpha-NAD(P)H-oxidase/anomerase." Biomeditsinskaya Khimiya 61.6 (2015): 667-679.
Severina, I. S., Fedchenko, V. I., Veselovsky, A. V., Medvedev, A. E. (2015). The history of renalase from amine oxidase to alpha-NAD(P)H-oxidase/anomerase. Biomeditsinskaya Khimiya, 61(6), 667-679.
Xu J., Li G., Wang P., Velazquez H., Yao X., Li Y., Wu Y., Peixoto A., Crowley S., Desir G.V. (2005) J. Clin. Invest., 115, 1275-1280. CrossRef Scholar google search
Zhao Q., Fan Z., He J., Chen S., Li H., Zhang P., Wang L., Hu D., Huang J., Qiang B., Gu D. (2007) J. Mol. Med., 85, 877-885. CrossRef Scholar google search
Ghosh S.S., Krieg R.J., Sica D.A., Wang R., Fakhry I., Gehr T. (2009) Pediatr Nephrol., 24, 367-377. Scholar google search
Wang Y., Liu F.Q., Wang D., Mu J.J., Ren K.Y., Guo T.S., Chu C., Wang L., Geng L.K., Yuan Z.Y. (2014) Medicine (Baltimore) 93 (6), e44. CrossRef Scholar google search
Wang Y., Chu C., Ren J., Mu J.J., Wang D., Liu F.Q., Ren K.Y., Guo T.S., Yuan Z.Y. (2014) Kidney Blood Press. Res., 39, 497-506. CrossRef Scholar google search
Wang Y., Wang D., Chu C., Mu J.J., Wang M, Liu F.Q., Xie B.Q., Yang F., Dong Z.Z., Yuan Z.Y. (2015) Cardiology, 130, 242-248. CrossRef Scholar google search
Quelhas-Santos J., Soares-Silva I., Fernandes-Cerqueira C., Simões-Silva L., Ferreira I., Carvalho C., Coentrão L., Vaz R., Sampaio-Maia B., Pestana M. (2014) Exp. Biol. Med. (Maywood), 239, 502-508. CrossRef Scholar google search
Guo X., Wang L., Velazquez H., Safirstein R., Desir G.V. (2014) Curr. Opin. Nephrol. Hypertens., 23, 513-518. CrossRef Scholar google search
Baroni S., Milani M., Pandini V., Pavesi G., Horner D., Aliverti A. (2013) Curr. Pharm. Des., 19, 2540-2551. CrossRef Scholar google search
Fedchenko V. I., Kaloshin A.A., Mezhevikina L.M., Buneeva O.A, Medvedev A.E. (2013) Int. J. Mol. Sci., 14, 12764-12779. CrossRef Scholar google search
Pandini V., Ciriello F., Tedeschi G., Rossoni G., Zanetti G., Aliverti A. (2010) Protein Expr. Purif., 72, 244-253. CrossRef Scholar google search
Milani M., Ciriello F., Baroni S., Pandini V., Canevari G., Bolognesi M., Aliverti A. (2011) J. Mol. Biol., 411, 463-473. CrossRef Scholar google search
Beaupre B.A., Carmichael B.R., Hoag M.R., Shah D.D., Moran G.R. (2013) J. Am. Chem. Soc., 135, 13980-13987. CrossRef Scholar google search
Hoag M.R., Roman J., Beaupre B.A., Silvaggi N.R., Moran G.R. (2015) Biochemistry, 54, 3791-3802. CrossRef Scholar google search
Li G., Xu J., Wang P., Velazquez H., Li Y., Wu Y., Desir G.V. (2008) Circulation, 117, 1277-1282. CrossRef Scholar google search
Wang Y., Xie B.Q., Gao W.H., Yan D.Y., Zheng W.L., Lu Y.B., Cao Y.M., Hu J.W., Yuan Z.Y., Mu J.J. (2015) Kidney Blood Press Res., 40, 605-613. CrossRef Scholar google search
Li X., Lin M., Xie Z., Huang R., Chen A.F., Jiang W. (2015) Herz, Nov 26. [Epub ahead of print]. Scholar google search
Zheng W.L., Wang J., Mu J.J., Liu F.Q., Yuan Z.Y., Wang Y., Wang D., Ren K.Y., Guo T.S., Xiao H.Y. (2015) Exp. Biol. Med. (Maywood), Nov 8. [Epub ahead of print]. Scholar google search
Quelhas-Santos J., Sampaio-Maia B., Simões-Silva L., Serrão P., Fernandes-Cerqueira C., Soares-Silva I., Pestana M. (2013) J. Hypertens., 31, 543-552. CrossRef Scholar google search
Desir G.V., Tang L., Wang P., Li G., Sampaio-Maia B., Quelhas-Santos J., Pestana M., Velazquez H. (2012) J. Am. Heart Assoc., 1(4), e002634. CrossRef Scholar google search
Quelhas-Santos J., Sampaio-Maia B., Remião F., Serrão P., Soares-Silva I., Desir G.V., Pestana M. (2015) Open Hypertension Journal, 7, 14-18. CrossRef Scholar google search
Guzik T.J., Mussa S., Gastaldi D., Sadowski J., Ratnatunga C., Pillai R., Channon K.M. (2002)Circulation, 105, 1656-1662. CrossRef Scholar google search
Kalinowski L., Malinski T. (2004) Acta Biochim Pol., 51, 459-469. Scholar google search
Chung H.Y., Baek B.S., Song S.H., Kim M.S., Im Huh J., Shim K.H., Kim K.W., Lee K.H. (1997) Age, 20, 127-140. CrossRef Scholar google search
Desco M.-C., Asensi M., Marquez R., Martinez-Valls J., Vento M., Pallardo F.V., Sastre J., Vina J. (2002) Diabetes, 51, 1118-1124. CrossRef Scholar google search
Beaupre B.A., Hoag M.R., Roman J., Forsterling F.H., Moran G.R. (2015) Biochemistry, 54, 795-806. CrossRef Scholar google search
Kaplan N.O., Ciotti M.M., Stolzenbach F.E., Bacher N.R. (1955) J. Am. Chem. Soc., 77, 815-816. CrossRef Scholar google search
Adachi J., Kumar C., Zhang Y., Olsen J.V., Mann M. (2006) Genome Biol. 7 (9), R80. Scholar google search
Kania K., Byrnes E.A., Beilby J.P., Webb S.A., Strong K.J. (2010) Ann. Clin. Biochem., 47(Pt. 2), 151-157. CrossRef Scholar google search
Shi W.B., Wang H.Y. (2015) Int. J. Clin. Exp. Med., 8, 9505-9511. Scholar google search
Wang Y., Chu C., Ren J., Mu J.J., Wang D., Liu F.Q., Ren K.Y., Guo T.S., Yuan Z.Y. (2014) Kidney Blood Press Res., 39, 497-506. Scholar google search
Zhang R., Li X., Liu N., Guo X., Liu W., Ning C., Wang Z., Sun L., Fu S. (2013) Neuromolecular Med., 15, 396-404. Scholar google search
Buraczynska M., Zukowski P., Buraczynska K., Mozul S., Ksiazek A. (2011) Neuromolecular Med., 13(4), 321-327. Scholar google search
Zhao Q., Fan Z., He J., Chen S., Li H., Zhang P., Wang L., Hu D., Huang J., Qiang B., Gu D. (2007) J. Mol. Med. (Berl), 85, 877-885. CrossRef Scholar google search
Guo X., Wang L., Velazquez H., Safirstein R., Desir G.V. (2014) Curr. Opin. Nephrol. Hypertens., 23, 513-518. CrossRef Scholar google search
Wang L., Velazquez H., Moeckel G., Chang J., Ham A., Lee H.T., Safirstein R., Desir G.V. (2014) J. Am. Soc. Nephrol., 25, 1226-1235. Scholar google search
Wang L., Velazquez H., Chang J., Safirstein R., Desir G.V. (2015) PLoS ONE, 10(4), e0122932. Scholar google search
