Molecular mechanisms of niclosamide antitumor activity

   
Moskaleva E.Yu.1 , Perevozchikova V.G.1, Zhirnik A.S.1, Severin S.E.1

1. National Research Centre “Kurchatov Institute”, NBICS-Centre, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20156106680      PubMed Id: 26716739
Year: 2015  Volume: 61  Issue: 6  Pages: 680-693
In this review the recent data regarding the antitumor activity of niclosamide and the molecular mechanisms of its antitumor activity are presented. Niclosamide has been used in the clinic for the treatment of intestinal parasite infections. In recent years in several screening investigations of various drugs and chemical compounds niclosamide was identified as a potential anticancer agent. Niclosamide not only inhibits the Wnt/b-catenin, mTORC1, STAT3, NF-kB and Notch signaling pathways, but also targets mitochondria in cancer cells to induce growth inhibition and apoptosis. A number of studies have established the anticancer activity of niclosamide in both in vitro and in vivo in xenotransplantation models using human tumors and immunodeficient mice. It is important that niclosamide is active not only against tumor cells but also cancer stem cells. Normal cells are resistant to niclosamide. The accumulated experimental data suggest niclosamide is a promising drug for the treatment of various types of cancer.
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Keywords: niclosamide, antitumor drugs, signaling pathways, mitochondria damage, cancer stem cells
Citation:

Moskaleva, E. Yu., Perevozchikova, V. G., Zhirnik, A. S., Severin, S. E. (2015). Molecular mechanisms of niclosamide antitumor activity. Biomeditsinskaya Khimiya, 61(6), 680-693.
This paper is also available as the English translation: 10.1134/S1990750815040022
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