Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives
The influence of (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives: 4-amino-3-(5-methyl-4- ethoxycarbonyl-(1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole (TF 4 CH 3 ) and 4,4’-bis(5-methel-4-ethoxycarbonyl-1H- 1,2,3-triazol-1-yl)-3,3’-azo-1,2,5-oxadiazole (2TF 4 CH 3 ) on stimulation of human platelet soluble guanylate cyclase by YC-1, NO-donors (sodium nitroprusside, SNP, and spermine NONO ) and on a synergistic increase of NO-dependent enzyme activation in the presence of YC-1 has been investigated. Both compounds increased guanylate cyclase activation by YC-1, potentiated guanylate cyclase stimulation by NO-donors and increased the synergistic effect of YC-1 on NO-dependent activation of soluble guanylate cyclase. The similarity in the properties of the examined TF 4 CH 3 and 2TF 4 CH 3 with that of YC-1 and the possible mechanism underlying the revealed properties of compounds used are discussed.
Severina I.S., Pyatakova N.V., Shchegolev A.Yu., Rozhkov V.Yu., Batog L.V., Makhova N.N. (2015) Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives. Biomeditsinskaya Khimiya, 61(6), 705-711.
Severina I.S. et al. Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 6. - P. 705-711.
Severina I.S. et al., "Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives." Biomeditsinskaya Khimiya 61.6 (2015): 705-711.
Severina, I. S., Pyatakova, N. V., Shchegolev, A. Yu., Rozhkov, V. Yu., Batog, L. V., Makhova, N. N. (2015). Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives. Biomeditsinskaya Khimiya, 61(6), 705-711.
