Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives

   
Severina I.S.1 , Pyatakova N.V.1, Shchegolev A.Yu.1, Rozhkov V.Yu.2, Batog L.V.2, Makhova N.N.2

1. Institute of Biomedical Chemistry, Moscow, Russia
2. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20156106705      PubMed Id: 26716741
Year: 2015  Volume: 61  Issue: 6  Pages: 705-711
The influence of (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives: 4-amino-3-(5-methyl-4- ethoxycarbonyl-(1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole (TF 4 CH 3 ) and 4,4’-bis(5-methel-4-ethoxycarbonyl-1H- 1,2,3-triazol-1-yl)-3,3’-azo-1,2,5-oxadiazole (2TF 4 CH 3 ) on stimulation of human platelet soluble guanylate cyclase by YC-1, NO-donors (sodium nitroprusside, SNP, and spermine NONO ) and on a synergistic increase of NO-dependent enzyme activation in the presence of YC-1 has been investigated. Both compounds increased guanylate cyclase activation by YC-1, potentiated guanylate cyclase stimulation by NO-donors and increased the synergistic effect of YC-1 on NO-dependent activation of soluble guanylate cyclase. The similarity in the properties of the examined TF 4 CH 3 and 2TF 4 CH 3 with that of YC-1 and the possible mechanism underlying the revealed properties of compounds used are discussed.
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Keywords: soluble guanylate cyclase, nitric oxidt, YC-1, (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives
Citation:

Severina, I. S., Pyatakova, N. V., Shchegolev, A. Yu., Rozhkov, V. Yu., Batog, L. V., Makhova, N. N. (2015). Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives. Biomeditsinskaya khimiya, 61(6), 705-711.
This paper is also available as the English translation: 10.1134/S1990750814010132
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