The immune status, components of the glutathione redox system, the activity of antioxidant enzymes and metabolism of purine nucleotides have been investigated in animals with experimental hypothyroidism. On day 8 after an increase in the number of leukocytes, lymphocytes, T-helpers and T-suppressors as well as increased number of B-lymphocytes was found in blood of thyroidectomized rats. This was accompanied by decreased activity of adenosine deaminase (AD), AMP-deaminase (AMPD), and 5'-nucleotidase (5'N) in blood, but the ratio of enzyme activity AD/AMPD increased. These changes in the activity of enzymes, involved in purine catabolism can beregarded as increased functional relationships between T and B lymphocytes in hypothyroidism. The functional changes of immune system cells were accompanied by increased activity of glutathione peroxidase (GPx), a decrease in the activity of superoxide dismutase (SOD), glutathione reductase (GR) and the ratio GH/GPx. Thyroidectomized rats had increased amounts of total, oxidized (GSSG) and reduced glutathione (GSH), but the ratio GSH/GSSG decerased as compared with control animals. In the liver, hypothyroidism resulted in activation of SOD, GPx, decreased activity of GR and decreased ratio GR/GPx. At the same time, the levels of total, oxidized, and reduced glutathione increased, but the ratio GSH/GSSG as well as activities of enzymes involved in purine nucleotide metabolism ratio (and their ratio 5'N/AD + AMPD) decreased. All these data suggest a functional relationship of the glutathione redox system not only with antioxidant enzymes, but also activity of enzymes involved purine nucleotide metabolism and immune status.
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Keywords: hypothyroidism, glutathione, glutathione reductase, enzymes of purine metabolism
Citation:
Tapbergenov S.O., Sovetov B.S., Bekbosynova R.B., Bolysbekova S.M. (2015) Glutathione redox system, immune status, antioxidant enzymes and metabolism of purine nucleotides in hypothyroidism. Biomeditsinskaya Khimiya, 61(6), 737-741.
Tapbergenov S.O. et al. Glutathione redox system, immune status, antioxidant enzymes and metabolism of purine nucleotides in hypothyroidism // Biomeditsinskaya Khimiya. - 2015. - V. 61. -N 6. - P. 737-741.
Tapbergenov S.O. et al., "Glutathione redox system, immune status, antioxidant enzymes and metabolism of purine nucleotides in hypothyroidism." Biomeditsinskaya Khimiya 61.6 (2015): 737-741.
Tapbergenov, S. O., Sovetov, B. S., Bekbosynova, R. B., Bolysbekova, S. M. (2015). Glutathione redox system, immune status, antioxidant enzymes and metabolism of purine nucleotides in hypothyroidism. Biomeditsinskaya Khimiya, 61(6), 737-741.
References
Gavrilin Yu.I., Khrushh V.T., Pogodin R.I. (1996) Schitovidnaya zheleza u detej: posledstviya Chernobylya. Minsk, 14-65. Scholar google search
Sokolovskij V.V. (2004) Vestnik SPb Gos. Med. Akad. im. Mechnikova, 4(5), 97-100. Scholar google search
Sokolovskij V.V. (2006) Sbornik izbrannykh trudov IV Mezhdunarodnogo Kongressa “Slabye i sverkhslabye polya i izlucheniya v biologii i meditsine”, ss. 121-131. Scholar google search
Moran L., Gutteridge J., Quinlan G. (2001) Curr. Med. Chem., 8(7), 763-772. Scholar google search
Tapbergenov S.O., Tapbergenov T.S. (2014) Stress, Adaptation and Adrenal-Thyroid Dysfunction Syndrome. ISBN:978-3-8465-2689-7, Saarbrucken, Germany, pp. 1-190. Scholar google search
Tapbergenov S.O., Tapbergenov T.S. (2005) Biomeditsinskaya khimiya, 51(2), 199-205. Scholar google search
Hirschhorn R. (1986) Clin. Immunol. Immunopathol., 40, 157-165. Scholar google search
Eckle T., Koeppen M., Eltzschig H.K. (2009) Physiology, 24(5), 298-306. Scholar google search
Aherne C.M., Kewley E.M., Eltzschig H. (2011) Biochim. Biophys. Acta, 5, 1329-1339. Scholar google search
Koeppen M., Eckle T., Eltzschig H.K. (2011) Adv. Pharm., 61, 145-186. Scholar google search
Tapbergenov S.O., Tapbergenov T.S. (2004) Meditsinskaya i klinicheskaya biokhimiya. ISBN:9965-652-77-5, Pavlodar, cc. 188-190. Scholar google search
Travina S.V. (1955) Rukovodstvo po biokhimicheskim issledovaniyam. M. Medgiz., cc. 253-255. Scholar google search
