Glutathione redox system, immune status, antioxidant enzymes and metabolism of purine nucleotides in hypothyroidism

   
Tapbergenov S.O.1 , Sovetov B.S.1, Bekbosynova R.B.1, Bolysbekova S.M.1

1. Semey State Medical University, Semey, Kazakhstan
Section: Experimental Study
DOI: 10.18097/PBMC20156106737      UDK: 612.017-577.121-616.441      PubMed Id: 26716746
Year: 2015  Volume: 61  Issue: 6  Pages: 737-741
The immune status, components of the glutathione redox system, the activity of antioxidant enzymes and metabolism of purine nucleotides have been investigated in animals with experimental hypothyroidism. On day 8 after an increase in the number of leukocytes, lymphocytes, T-helpers and T-suppressors as well as increased number of B-lymphocytes was found in blood of thyroidectomized rats. This was accompanied by decreased activity of adenosine deaminase (AD), AMP-deaminase (AMPD), and 5'-nucleotidase (5'N) in blood, but the ratio of enzyme activity AD/AMPD increased. These changes in the activity of enzymes, involved in purine catabolism can beregarded as increased functional relationships between T and B lymphocytes in hypothyroidism. The functional changes of immune system cells were accompanied by increased activity of glutathione peroxidase (GPx), a decrease in the activity of superoxide dismutase (SOD), glutathione reductase (GR) and the ratio GH/GPx. Thyroidectomized rats had increased amounts of total, oxidized (GSSG) and reduced glutathione (GSH), but the ratio GSH/GSSG decerased as compared with control animals. In the liver, hypothyroidism resulted in activation of SOD, GPx, decreased activity of GR and decreased ratio GR/GPx. At the same time, the levels of total, oxidized, and reduced glutathione increased, but the ratio GSH/GSSG as well as activities of enzymes involved in purine nucleotide metabolism ratio (and their ratio 5'N/AD + AMPD) decreased. All these data suggest a functional relationship of the glutathione redox system not only with antioxidant enzymes, but also activity of enzymes involved purine nucleotide metabolism and immune status.
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Tapbergenov S.O., Sovetov B.S., Bekbosynova R.B., Bolysbekova S.M. (2015) Biomeditsinskaya khimiya, 61(6), 737-741.
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