Express evaluation of antioxidant activity of uracil derivatives

   
Gimadieva A.R.1 , Khazimullina Yu.Z.2, Belaya E.A.1, Zimin Yu.S.3, Abdrakhmanov I.B.4, Mustafin A.G.5

1. Ufa Institute of Chemistry of the Russian Academy of Sciences, Ufa, Russia
2. Bashkir State Agrarian University, Ufa, Russia
3. Bashkir State University, Ufa, Russia
4. Ufa Institute of Chemistry of the Russian Academy of Sciences, Ufa, Russia; Bashkir State Agrarian University, Ufa, Russia
5. Ufa Institute of Chemistry of the Russian Academy of Sciences, Ufa, Russia; Bashkir State University, Ufa, Russia
Section: Short Communication
DOI: 10.18097/PBMC20156106765      UDK: 543.421: 547.854.4      PubMed Id: 26716750
Year: 2015  Volume: 61  Issue: 6  Pages: 765-769
Using photometric methods the antioxidant activity of 19 uracil derivatives has been analyzed. The test using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals can be applied for the rapid assessment ofantioxidant activity ofuracils. Among uracil derivatives studied thecompounds possesing a proton-donor group in C-5 position – free or alkylated amino group, as well as hydroxyl group were the most active: 5-aminouracil (IC 50 3 mg/ml), 5-amino-6-methyluracil (IC 50 of 5 mg/ml), 5-hydroxy-6-methyluracil (IC 50 of 15 mg/ml), 5-hydroxy-1,3,6-trimethyluracil (IC 50 of 15 mg/ml), 5-ethylamino-6-methyluracil (IC 50 of 20 mg/ml), 5-methylamino-6-methyluracil (IC 50 of 20 mg/ml), 5-allylaminouracil (IC 50 of 20 mg/ml), 5-amino-1,3,6- trimethyluracil (IC 50 of 25 mg/ml). These uracil derivatives were more active than the reference compounds ionol (IC 50 of 30 mg/ml) and a-naphthylamine (IC 50 of 45 mg/ml), but less active than ascorbic acid (IC 50 0.8 mg/ml). There was a correlation between the results of DPPH test (IC 50 ) and coupling constants of uracil derivatives with peroxide radicals of 1,4-dioxane (fk 7 ). Uracil with proton-donor group at C-5 also showed high ferrum-reducing activity as determined by FRAP.
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Gimadieva A.R., Khazimullina Yu.Z., Belaya E.A., Zimin Yu.S., Abdrakhmanov I.B., Mustafin A.G. (2015) Biomeditsinskaya khimiya, 61(6), 765-769.
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