Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives

   
Popov A.M.1 , Krivoshapko O.N.2, Klimovich A.A.2, Artyukov A.A.2

1. Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia; Far Eastern Federal University, Vladivostok, Russia
2. Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia
Section: Review
DOI: 10.18097/PBMC20166201022      PubMed Id: 26973183
Year: 2016  Volume: 62  Issue: 1  Pages: 22-30
The review considers recent experimental studies of biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives in diseases associated with disorders of carbohydrate and lipid metabolism. Particular attention is focused on the results of studies showing a high therapeutic potential of these phenolic compounds in their prophylactic and therapeutic use at experimental modeling of type 2 diabetes and hyperlipidemia. Based on the analysis of our results and the literature data putative mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives have been proposed.
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Keywords: flavonoids, luteolin, rosmarinic acid, type 2 diabetes, hyperlipidemia, atherosclerosis
Citation:

Popov, A. M., Krivoshapko, O. N., Klimovich, A. A., Artyukov, A. A. (2016). Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives. Biomeditsinskaya khimiya, 62(1), 22-30.
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