Effect of radio frequency discharge plasma on surface properties and biocompatibility of polycaprolactone matrices

Bolbasov E.N.1, Antonova L.V.2 , Matveeva V.G.2, Novikov V.A.3, Shesterikov E.V.1, Bogomolova N.L.1, Golovkin A.S.2, Tverdohlebov S.I.1, Barbarash O.L.2, Barbarash L.S.2

1. National Research Tomsk Polytechnic University, Tomsk, Russia
2. Research Institute for Complex Issues of Cardiovascular Disease, Kemerovo, Russia
3. National Research Tomsk State University, Tomsk, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20166201056      UDK: 577.11:544.558      PubMed Id: 26973188
Year: 2016  Volume: 62  Issue: 1  Pages: 56-63
Surface modification of bioresorbable polymer material (polycaprolactone, PCL) with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target was investigated. Plasma treatment resulted in an increase of surface roughness of PCL, crystallite size, the surface free energy and hydrophilicity. Increased treatment time (30, 60, 150 seconds) provoked the polymer surface saturation with the sputtering target ions (calcium, phosphorus). The assessment of plasma exposure of PCL surface on bone marrow multipotent mesenchymal stromal cells behavior (BM MSCs) has been performed. Modification of the polymer surface with the abnormal glow discharge stimulated adhesion and subsequent proliferation of BM MSCs; thus, maximum values were achieved with the surface treatment for 60 s. This type of plasma modification did not affect cell viability (apoptosis, necrosis). Thus, the surface modification with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target, appear to be a promising method of surface modification of bioresorbable polymer material (PCL) for tissue engineering.
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Bolbasov E.N., Antonova L.V., Matveeva V.G., Novikov V.A., Shesterikov E.V., Bogomolova N.L., Golovkin A.S., Tverdohlebov S.I., Barbarash O.L., Barbarash L.S. (2016) Biomeditsinskaya khimiya, 62(1), 56-63.
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